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首页> 外文期刊>Disease Prevention Daily. >Research on Colon Cancer Published by Researchers at Monash University (Epigenetic Drift Association with Cancer Risk and Survival, and Modification by Sex)
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Research on Colon Cancer Published by Researchers at Monash University (Epigenetic Drift Association with Cancer Risk and Survival, and Modification by Sex)

机译：结肠癌研究人员发布的研究莫纳什大学(表观遗传漂移与癌症风险和生存修改性)

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2021 MAY 03 (NewsRx) - By a News Reporter-Staff News Editor at Disease Prevention Daily - A new study on colon cancer is now available. According to news originating from Clayton, Australia, by NewsRx editors, the research stated, "To investigate age- and sex-specific DNA methylation alterations related to cancer risk and survival, we used matched case-control studies of colorectal (* * n* * = 835), gastric (* * n* * = 170), kidney (* * n* * = 143), lung (* * n* * = 332), prostate (* * n* * = 869) and urothelial (* * n* * = 428) cancers, and mature B-cell lymphoma (* * n* * = 438). Linear mixed-effects models were conducted to identify age-, sex- and age-by-sex-associated methylation markers using a discovery (controls)-replication (cases) strategy." The news editors obtained a quote from the research from Monash University: "Replication was further examined using summary statistics from Generation Scotland (GS). Associations between replicated markers and risk of and survival from cancer were assessed using conditional logistic regression and Cox models (hazard ratios (HR)), respectively. We found 32,659, 23,141 and 48 CpGs with replicated associations for age, sex and age-by-sex, respectively. The replication rates for these CpGs using GS summary data were 94%, 86% and 91%, respectively. Significant associations for cancer risk and survival were identified at some individual age-related CpGs. Opposite to previous findings using epigenetic clocks, there was a strong negative trend in the association between epigenetic drift and risk of colorectal cancer."
机译：2021年5月03 (NewsRx)——由一个新闻记者新闻编辑在日常——一种新的疾病预防研究结肠癌目前可用。澳大利亚新闻来自克莱顿NewsRx编辑,研究指出:“调查年龄和性别DNA甲基化改变与癌症风险和生存有关,我们使用匹配的病例对照研究结直肠(* * n * * = 835),胃(* * n * * =170)、肾(* * * * n = 143)、肺(* * n * * =332)、前列腺(* * n * * = 869)和移行细胞(** * * n = 428)癌症,和成熟b细胞淋巴瘤(* * * * n = 438)。进行了识别年龄,性别,age-by-sex-associated甲基化标记使用发现(控制)复制(例)战略。”莫纳什大学的研究:“复制进一步研究使用摘要统计信息苏格兰(GS)。之间复制标记和和的风险癌症存活率进行了评估条件逻辑回归和Cox模型(分别为风险比率(人力资源))。32659年、23141年和48论文认定与复制协会对年龄、性别和age-by-sex,分别。论文认定使用GS总结数据分别为94%、86%和91%,分别。风险和生存在一些被确定个人与年龄相关的论文认定。发现使用表观遗传的时钟,强烈的负面趋势之间的关系表观遗传漂移和结肠直肠癌的风险。”

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