Cyclin D2 in the basal process of neural progenitors is linked to non-equivalent cell fates

TsunekawaY.; BrittoJ.M.; TakahashiM.PolleuxF.TanS.-S.OsumiN.

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Cyclin D2 in the basal process of neural progenitors is linked to non-equivalent cell fates

机译：细胞周期蛋白D2的基底神经的过程祖细胞与等效单元命运

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Asymmetric cell division plays an indispensable role during corticogenesis for producing new neurons while maintaining a self-renewing pool of apical progenitors. The cellular and molecular determinants favouring asymmetric division are not completely understood. Here, we identify a novel mechanism for generating cellular asymmetry through the active transportation and local translation of Cyclin D2 mRNA in the basal process. This process is regulated by a unique cis-regulatory sequence found in the 3′ untranslated region (3′UTR) of the mRNA. Unequal inheritance of Cyclin D2 protein to the basally positioned daughter cell with the basal process confers renewal of the apical progenitor after asymmetric division. Conversely, depletion of Cyclin D2 in the apically positioned daughter cell results in terminal neuronal differentiation. We demonstrate that Cyclin D2 is also expressed in the developing human cortex within similar domains, thus indicating that its role as a fate determinant is ancient and conserved.

机译：不对称细胞分裂中起着不可或缺的在corticogenesis产生新的角色神经元,同时保持自我更新的顶端的祖细胞。决定因素有利于不对称分裂没有完全理解。小说生成细胞不对称的机制通过主动运输和地方翻译的基底细胞周期蛋白D2 mRNA的过程。基因序列中发现3 '信使核糖核酸的翻译区(3 'utr)。继承的基底细胞周期蛋白D2蛋白质定位子细胞与基底的过程授予顶端祖后的更新不对称分裂。细胞周期蛋白D2的顶端被定位的女儿神经细胞导致终端分化。也表达了人类在发展中皮层在类似的领域,从而表明它作为古代和命运的决定因素守恒的。

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来源
《EMBO Journal》 |2012年第8期|1879-1892|共14页
作者
TsunekawaY.; BrittoJ.M.; TakahashiM.PolleuxF.TanS.-S.OsumiN.;
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作者单位

Department of Cell Biology, Dorris Neuroscience Center, Scripps Research Institute, San Diego, CA;

Brain Development and Regeneration Laboratory, Florey Neuroscience Institutes, University of;

Division of Developmental Neuroscience, United Core Centers for Advanced Research and Translational;

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正文语种英语
中图分类分子生物学;分子生物学;
关键词
Cyclin D2; Asymmetric Cell Division; Neuronal Differentiationdaughter cellprecursors;

机译：细胞周期蛋白D2;不对称细胞分裂;神经元Differentiationdaughter cellprecursors;

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Cyclin D2 in the basal process of neural progenitors is linked to non-equivalent cell fates

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