The demise of a TUDOR under stress opens a chromatin link to 53BP1

StewartG.S.

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The demise of a TUDOR under stress opens a chromatin link to 53BP1

机译：都铎式压力下打开的灭亡染色质53 bp1的链接

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The mechanisms that localise 53BP1 to sites of DNA double-strand breaks (DSBs) have remained elusive, despite this protein's key roles in DNA damage response signalling and repair processes. Recent studies, including the work by Mallette et al (2012) in this issue of The EMBO Journal, now provide crucial insights into the roles of ubiquitin-dependent signalling cascades at DNA damage sites required for chromatin-mediated 53BP1 recruitment.

机译：本土化53 bp1的机制,网站的DNA双链断裂(双边带)难以捉摸的,尽管这种蛋白质的DNA的重要角色破坏响应信号和修复过程。最近的研究,包括玛丽特的工作等艾尔EMBO杂志(2012)在这个问题上,现在提供至关重要的见解的角色在DNA ubiquitin-dependent信号级联chromatin-mediated所需破坏网站53 bp1招聘。

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来源
《EMBO Journal》 |2012年第8期|1847-1849|共3页
作者
StewartG.S.;
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作者单位

School of Cancer Sciences, University of Birmingham, Birmingham, United Kingdom;

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原文格式 PDF
正文语种英语
中图分类分子生物学;分子生物学;
关键词
DNA Damage; Chromatin; Tumor Suppressor p53-Binding Protein 1;

机译：DNA损伤,染色质;肿瘤抑制p53-Binding蛋白1;

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5. Structural basis for recognition of 53BP1 tandem Tudor domain by TIRR [J] . Yaxin Dai, Aili Zhang, Shan Shan, Nature Communications . 2018,第1期

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6. Switching 53BP1 on and off via Tudors [J] . Zhang Yi, Kutateladze Tatiana G. Nature structural & molecular biology . 2018,第8期

机译：通过Tudors开启和关闭53bp1
7. Structural Plasticity of Methyllysine Recognition by the Tandem Tudor Domain of 53BP1 [J] . Tong Qiong, Cui Gaofeng, Botuyan Maria Victoria, Structure . 2015,第2期

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8. Design for Demise: Systems-level techniques to reduce re-entry casualty risk [C] . David Riley, Irene Pontijas Fuentes, Jan-Christian Meyer, International Astronautical Congress . 2017

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9. The identification of proteins interacting with the 53BP1 tandem tudor domains [D] . Chang, Kai-wei 2008

机译：与53BP1串联Tudor结构域相互作用的蛋白质的鉴定
10. The demise of a TUDOR under stress opens a chromatin link to 53BP1 [O] . Grant S Stewart 2012

机译：TUDOR在压力下的死亡打开了与53BP1的染色质链接
11. Structural basis for recognition of 53BP1 tandem Tudor domain by TIRR [O] . Yaxin Dai, Aili Zhang, Shan Shan, 2018

机译：TIRR的识别53BP1 TANDEM TUDOR域的结构基础
12. Eindverslag LINK02: Een Onderzoek naar TCP/IP (Terminal Report LINK02: A Study of TCP/IP) [R] . Mandour, Y. M. T. , Dekker, R. 1987

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The demise of a TUDOR under stress opens a chromatin link to 53BP1

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