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首页> 外文期刊>EMBO Journal >Gcn4p-mediated transcriptional repression of ribosomal protein genes under amino-acid starvation.
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Gcn4p-mediated transcriptional repression of ribosomal protein genes under amino-acid starvation.

机译：Gcn4p-mediated转录镇压核糖体蛋白基因的氨基酸饥饿。

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摘要

Gcn4p is a well-characterized bZIP transcription factor that activates more than 500 genes encoding amino acids and purine biosynthesis enzymes, and many stress-response genes under various stress conditions. Under these stresses, it had been shown that transcriptions of ribosomal protein (RP) genes were decreased. However, the detailed mechanism of this downregulation has not been elucidated. In this study, we present a novel mechanistic model for a repressive role of Gcn4p on RP transcription, especially under amino-acid starvation. It was found that Gcn4p bound directly to Rap1p, which in turn inhibited Esa1p-Rap1p binding. The inhibition of Esa1p recruitment to RP promoters ultimately reduced the level of histone H4 acetylation and RP transcription. These data revealed that Gcn4p has simultaneous dual roles as a repressor for RP genes as well as an activator for amino-acid biosynthesis genes. Moreover, our results showed evidence of a novel link between general control of amino-acid biosynthesis and ribosome biogenesis mediated by Gcn4p at an early stage of adaptation to amino-acid starvation.
机译：Gcn4p特征明显是bZIP转录因素激活超过500个基因编码氨基酸,嘌呤生物合成酶,许多应激反应基因各种压力条件。它一直显示音标核糖体蛋白基因(RP)下降。然而,详细的机制downregulation尚未阐明。研究中,我们提出一个新颖的机械模型压抑的角色Gcn4p RP转录,特别是在氨基酸饥饿。发现Gcn4p直接绑定到Rap1p,反过来抑制Esa1p-Rap1p绑定。抑制Esa1p招聘RP推动者最终减少了组蛋白H4的水平乙酰化作用和RP转录。透露,Gcn4p同时双重角色作为RP基因的抑制因子以及一个催化剂对氨基酸生物合成基因。此外,我们的研究结果显示证据的一部小说氨基酸的一般控制之间的联系生物合成和核糖体生物起源由Gcn4p适应的早期阶段氨基酸饥饿。

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