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首页> 外文期刊>Advanced Biosystems >Organic Electrochemical Transistor Arrays for In Vitro Electrophysiology Monitoring of 2D and 3D Cardiac Tissues
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Organic Electrochemical Transistor Arrays for In Vitro Electrophysiology Monitoring of 2D and 3D Cardiac Tissues

机译：有机电化学晶体管阵列体外电生理监测2 d和3 d心脏组织

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摘要

Here, a multichannel organic electrochemical transistor (OECT) array is reported for electrophysiological monitoring and mapping of action potential propagation of a wide range of cardiac cells, including cell lines, primary cell lines, and human-sourced stem cell derivatives in 2D and 3D structures. The results suggest that the ability to exploit this OECT-based platform to map 2D action potential propagation provides a viable strategy to better characterize cardiac cells in response to various chronotropic drugs. The effects of chronotropic agents Isoproterenol and Verapamil on cardiac tissues validate the utility of OECT for drug screening capability, and a preliminary demonstration of a 64-channel OECT array to monitor the cardiac action potentials for better spatial resolution is presented. The study demonstrates that OECT will be a viable and versatile platform for applications in medical and pharmacological industries.
机译：在这里,一个多通道有机电化学晶体管(OECT)数组报道电生理监测和映射的动作电位范围广泛的传播心肌细胞,包括细胞系,原代细胞行,human-sourced干细胞衍生品2 d和3 d结构。利用这个OECT-based平台的能力绘制2 d动作电位传播提供了一个可行的策略,以更好地描述心脏细胞在回应各种变时性的药物。变时性的代理异丙肾上腺素的影响和维拉帕米对心脏组织验证效用的OECT药物筛选功能,和64 -通道的初步演示OECT数组来监测心脏行动潜力更好的空间分辨率提出了。是一个可行的和通用的平台应用在医学和药理行业。

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