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Phage therapy of pulmonary infections

机译：肺感染的噬菌体疗法

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It is generally agreed that a bacteriophage-associated phenomenon was first unambiguously observed one-hundred years ago with the findings of Twort in 1915. This was independently followed by complementary observations by d'Hérelle in 1917. D'Hérelle's appreciation of the bacteriophage phenomenon appears to have directly led to the development of phages as antibacterial agents within a variety of contexts, including medical and agricultural. Phage use to combat nuisance bacteria appears to be especially useful where targets are sufficiently problematic, suitably bactericidal phages exist, and alternative approaches are lacking in effectiveness, availability, safety, or cost effectiveness, etc. Phage development as antibacterial agents has been strongest particularly when antibiotics have been less available or useful, e.g., such as in the treatment of chronic infections by antibiotic-resistant bacteria. One relatively under-explored or at least not highly reported use of phages as therapeutic agents has been to combat bacterial infections of the lungs and associated tissues. These infections are diverse in terms of their etiologies, manifestations, and also in terms of potential strategies of phage delivery. Here I review the literature considering the phage therapy of pulmonary and pulmonary-related infections, with emphasis on reports of clinical treatment along with experimental treatment of pulmonary infections using animal models.
机译：人们普遍认为bacteriophage-associated现象第一次明确观察到一百年前在1915年的发现Twort。其次是互补独立观察d 'Herelle于1917年。升值的噬菌体的现象似乎直接导致了发展噬菌体作为内的抗菌药物各种环境,包括医疗和农业。细菌似乎特别有用目标是充分的问题,适当杀菌噬菌体存在,和替代方法都缺乏有效性,可用性、安全性、成本效益等。噬菌体抗菌药物发展最强的特别是当抗生素不提供或有用的,例如,如在慢性感染的治疗抗生素耐药的细菌。有待进一步研究或者至少不是高度报道利用噬菌体治疗制剂一直是对抗细菌感染的肺部和相关的组织。的病因、症状和还在噬菌体的潜在策略交付。考虑到噬菌体治疗肺和与肺病相关的感染,与强调临床治疗的报道实验治疗肺部感染使用动物模型。

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