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首页> 外文期刊>EMBO Journal >Arabidopsis MAP kinase 4 regulates gene expression through transcription factor release in the nucleus
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Arabidopsis MAP kinase 4 regulates gene expression through transcription factor release in the nucleus

机译：拟南芥MAP激酶4调节基因表达通过转录因子释放的核

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摘要

Plant and animal perception of microbes through pathogen surveillance proteins leads to MAP kinase signalling and the expression of defence genes. However, little is known about how plant MAP kinases regulate specific gene expression. We report that, in the absence of pathogens, Arabidopsis MAP kinase 4 (MPK4) exists in nuclear complexes with the WRKY33 transcription factor. This complex depends on the MPK4 substrate MKS1. Challenge with Pseudomonas syringae or flagellin leads to the activation of MPK4 and phosphorylation of MKS1. Subsequently, complexes with MKS1 and WRKY33 are released from MPK4, and WRKY33 targets the promoter of PHYTOALEXIN DEFICIENT3 (PAD3) encoding an enzyme required for the synthesis of antimicrobial camalexin. Hence, wrky33 mutants are impaired in the accumulation of PAD3 mRNA and camalexin production upon infection. That WRKY33 is an effector of MPK4 is further supported by the suppression of PAD3 expression in mpk4-wrky33 double mutant backgrounds. Our data establish direct links between MPK4 and innate immunity and provide an example of how a plant MAP kinase can regulate gene expression by releasing transcription factors in the nucleus upon activation.
机译：微生物在植物和动物的看法病原体监测蛋白质导致地图激酶信号和国防的表达基因。地图激酶调节特定基因的表达。报告说,在缺乏病原体,拟南芥MAP激酶4 (MPK4)存在于核与WRKY33转录因子复合物。这个复杂取决于MPK4衬底MKS1。挑战有两或鞭毛蛋白导致MPK4的激活MKS1磷酸化。从MPK4 MKS1和WRKY33被释放,WRKY33目标植物抗毒素的启动子DEFICIENT3 (PAD3)编码所需的酶的合成抗菌camalexin。wrky33突变体受损的积累PAD3 mRNA和camalexin生产感染。PAD3进一步支持的抑制表达mpk4-wrky33双突变体背景。MPK4和先天免疫之间提供一个如何调节植物MAP激酶的例子通过释放转录基因表达在激活因素在细胞核中。

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