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Innate and acquired bacteriophage-mediated immunity

机译：先天和后天bacteriophage-mediated免疫力

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摘要

We recently described a novel, non-host-derived, phage-mediated immunity active at mucosal surfaces, the main site of pathogen entry in metazoans. In that work, we showed that phage T4 adheres to mucus glycoproteins via immunoglobulin-like domains displayed on its capsid. This adherence positions the phage in mucus surfaces where they are more likely to encounter and kill bacteria, thereby benefiting both the phage and its metazoan host. We presented this phage-metazoan symbiosis based on an exclusively lytic model of phage infection. Here we extend our bacteriophage adherence to mucus (BAM) model to consider the undoubtedly more complex dynamics in vivo. We hypothesize how mucus-adherent phages, both lytic and temperate, might impact the commensalmicrobiota as well as protect the metazoan epithelium from bacterial invasion. We suggest that BAM may provide both an innate and an acquired antimicrobial immunity.
机译：我们最近一部小说,描述non-host-derived,phage-mediated在粘膜免疫活性表面,主要的病原体进入网站后生动物。坚持粘液糖蛋白通过immunoglobulin-like域上显示它衣壳。粘液的表面更容易遇到和杀死细菌,从而受益噬菌体和后生动物宿主。提出这个phage-metazoan共生的基础上噬菌体感染的完全分解模型。我们扩展我们的噬菌体坚持粘液(BAM)模型考虑无疑更复杂的体内动力学。mucus-adherent噬菌体裂解和温带,commensalmicrobiota以及可能的影响从细菌保护后生动物的上皮细胞入侵。先天和后天抗菌免疫。

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