The human synMuv-like protein LIN-9 is required for transcription of G2/M genes and for entry into mitosis

Osterloh L; von Eyss B; Schmit FRein LHubner DSamans BHauser SGaubatz S

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The human synMuv-like protein LIN-9 is required for transcription of G2/M genes and for entry into mitosis

机译：人类synMuv-like蛋白质LIN-9是必需的G2 / M基因的转录和条目在有丝分裂

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Regulated gene expression is critical for the proper timing of cell cycle transitions. Here we report that human LIN-9 has an important function in transcriptional regulation of G2/M genes. Depletion of LIN-9 by RNAi in human fibroblasts strongly impairs proliferation and delays progression from G2 to M. We identify a cluster of G2/M genes as direct targets of LIN-9. Activation of these genes is linked to an association between LIN-9 and B-MYB. Chromatin immunoprecipitation assays revealed binding of both LIN-9 and B-MYB to the promoters of G2/M regulated genes. Depletion of B-MYB recapitulated the biological outcome of LIN-9 knockdown, including impaired proliferation and reduced expression of G2/M genes. These data suggest a critical role for human LIN-9, together with B-MYB, in the activation of genes that are essential for progression into mitosis.

机译：调节基因表达的是至关重要的适当的细胞周期转换的时机。报告说,人类LIN-9有着重要的作用在G2 / M基因的转录调控。损耗的LIN-9 RNAi人类成纤维细胞强烈影响扩散和延迟发展从G2到m .我们确定一个集群G2 / M基因直接LIN-9的目标。激活这些基因与一个LIN-9和B-MYB之间的联系。免疫沉淀反应化验显示绑定的LIN-9和B-MYB G2 / M的推动者调节基因。的生物学结果LIN-9击倒,包括受损的扩散和减少G2 / M基因的表达。关键作用对人类LIN-9,一起B-MYB,基因的激活必不可少的发展进入有丝分裂。

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来源
《EMBO Journal》 |2007年第1期|144-157|共14页
作者
Osterloh L; von Eyss B; Schmit FRein LHubner DSamans BHauser SGaubatz S;
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作者单位

Univ Marburg, Inst Mol Biol & Tumor Res, Marburg, Germany;

Univ Wurzburg, Dept Physiol Chem 1, Bioctr, D-97074 Wurzburg, Germany;

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原文格式 PDF
正文语种英语
中图分类分子生物学;
关键词
Genomic Instability; DNA Replication; MitosisGenesprogressionsCell CycleS PhaseMYBL2 protein, humanDrosophilaMitotic Checkpointsentry;

机译：DNA基因组不稳定性;复制;MitosisGenesprogressionsCell周期PhaseMYBL2蛋白质,humanDrosophilaMitoticCheckpointsentry;

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The human synMuv-like protein LIN-9 is required for transcription of G2/M genes and for entry into mitosis

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