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首页> 外文期刊>EMBO Journal >Chromatin at the crossroads. Meeting on Signalling to Chromatin Epigenetics
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Chromatin at the crossroads. Meeting on Signalling to Chromatin Epigenetics

机译：染色质在十字路口。对染色质表观遗传学

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摘要

In June 2006, about 90 scientists came together at the Wellcome Trust Conference Centre in Hinxton (near Cambridge, UK), to attend the first European Science Foundation (ESF)–Wellcome Trust Conference on Signalling to Chromatin Epigenetics. This meeting addressed how cellular processes both signal and respond to chromatin. Chromatin is composed of nucleosomes that each comprise 147 base pairs of DNA wrapped around an octamer of two copies of each histone H2A, H2B, H3 and H4. Nucleosomes are folded into higher-order structures that are stabilized by linker histones. Chromatin structure can be altered by enzymes that post-translationally modify histones (for example, through phosphorylation, acetylation, methylation or ubiquitination) or by ATP-driven chromatin-remodelling complexes that alter nucleosome position and/or composition. The role of chromatin in cellular processes, such as transcription, DNA-damage repair and cell differentiation, was discussed at the meeting. In this report, we summarize a few of the highlights from the broad range of topics discussed.
机译：2006年6月,约90名科学家聚集在一起威康信托基金会Hinxton会议中心(英国剑桥附近),参加第一欧洲科学基金会(养)威康信托基金会议表明染色质表观遗传学。过程信号和响应染色质。染色质组成的核小体DNA缠绕在一个包含147个碱基对的八聚物的两个副本,每个组蛋白H2A、H2B,H3和H4。稳定的高阶结构链接器组蛋白。改变你的酶修改组蛋白(例如,通过磷酸化、乙酰化、甲基化或泛素化)或ATP-drivenchromatin-remodelling复合物,改变核小体的位置和/或成分。染色质的细胞过程,如转录、dna损伤修复和细胞分化,在会上讨论。这个报告中,我们总结的一些亮点广泛的话题进行了讨论。

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