NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity

Nakazawa T; Komai S; Watabe AMKiyama YFukaya MArima-Yoshida FHorai RSudo KEbine KDelawary M

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NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity

机译：NR2B酪氨酸磷酸化调节的恐惧学习以及杏仁突触可塑性

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Phosphorylation of neural proteins in response to a diverse array of external stimuli is one of the main mechanisms underlying dynamic changes in neural circuitry. The NR2B subunit of the NMDA receptor is tyrosine-phosphorylated in the brain, with Tyr-1472 its major phosphorylation site. Here, we generate mice with a knockin mutation of the Tyr-1472 site to phenylalanine ( Y1472F) and show that Tyr-1472 phosphorylation is essential for fear learning and amygdaloid synaptic plasticity. The knockin mice show impaired fear-related learning and reduced amygdaloid long-term potentiation. NMDA receptor-mediated CaMKII signaling is impaired in YF/YF mice. Electron microscopic analyses reveal that the Y1472F mutant of the NR2B subunit shows improper localization at synapses in the amygdala. We thus identify Tyr-1472 phosphorylation as a key mediator of fear learning and amygdaloid synaptic plasticity.

机译：神经蛋白的磷酸化反应多样化的外部刺激的动态变化的主要机制神经回路。受体酪氨酸磷酸化在大脑中,其主要磷酸化酪氨酸- 1472网站。在这里,我们生成兄弟突变的老鼠酪氨酸- 1472网站苯丙氨酸(Y1472F)和表明,酪氨酸- 1472磷酸化是至关重要的因为害怕学习和杏仁突触可塑性。忍受与学习和杏仁长期的增强作用。CaMKII信号在YF / YF小鼠受损。电子显微镜分析显示,Y1472F突变NR2B亚单位的显示不正确本地化在杏仁核的突触。识别磷酸化酪氨酸- 1472作为一个关键学习和杏仁突触调停者的恐惧可塑性。

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《EMBO Journal》 |2006年第12期|2867-2877|共11页
作者
Nakazawa T; Komai S; Watabe AMKiyama YFukaya MArima-Yoshida FHorai RSudo KEbine KDelawary M;
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alliativecare.org;

Univ Tokyo, Dept Basic Med Sci, Div Neuronal Network, Tokyo 1088639, Japan;

Univ Tokyo, Inst Med Sci, Ctr Med Expt, Tokyo 1088639, JapanHokkaido Univ, Sch Med, Dept Anat, Sapporo, Hokkaido 060, JapanJapan Sci & Technol Agcy, CREST, Tokyo, JapanUniv Tokyo, Ist Sci Med, Dept Canc Biol, Div Oncol, Tokyo 1088639, Japan;

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正文语种英语
中图分类分子生物学;分子生物学;
关键词
Amygdaloid (igneous rock); Amygdala; aspartic acid receptorProteinSynapsesLong-Term PotentiationSynaptic plasticityn methyl dextro aspartic acid receptorTyrosine Phosphorylation;

机译：杏仁(火成岩);杏仁核,天冬氨酸receptorProteinSynapsesLong-TermPotentiationSynaptic plasticityn甲基右旋的天冬氨酸receptorTyrosine磷酸化;

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NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity

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