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首页> 外文期刊>EMBO Journal >B-cell activation by membrane-bound antigens is facilitated by the interaction of VLA-4 with VCAM-1
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B-cell activation by membrane-bound antigens is facilitated by the interaction of VLA-4 with VCAM-1

机译：被包围的b细胞活化抗原通过VLA-4之间的相互作用VCAM-1

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摘要

VCAM-1 is one of the main ligands of VLA-4, an integrin that is highly expressed on the surface of mature B cells. Here we find that coexpression of VCAM-1 on an antigen-bearing membrane facilitates B-cell activation. Firstly, this is achieved by mediating B-cell tethering, which in turn increases the likelihood of a B cell to be activated. Secondly, VLA-4 synergizes with the B-cell receptor (BCR), providing B cells with tight adhesion and enhanced signalling. This dual role of VCAM-1 in promoting B-cell activation is predominantly effective when the affinity of the BCR for the antigen is low. In addition, we show that the VCAM-1 ectodomain alone is sufficient to carry out this function. However, it requires the transmembrane domain to segregate properly into a docking structure characteristic of the B-cell immunological synapse (IS). These results show that the VLA-4/VCAM-1 interaction during membrane antigen recognition enhances B-cell activation and this function appears to be independent of its final peripheral localization at the IS.
机译：VCAM-1是VLA-4的主要配体之一,一个整合素表面高度表达成熟的B细胞。的VCAM-1 antigen-bearing膜促进b细胞活化。通过调节b细胞拘束,又增加了一个B细胞的可能性激活。B细胞受体(BCR),提供B细胞紧粘附和增强的信号。VCAM-1的角色在促进b细胞活化主要的亲和力时有效对抗原的BCR很低。, VCAM-1 ectodomain单独是充分的执行这个函数。跨膜域正确隔离成对接结构b细胞的特征免疫突触(是)。在膜VLA-4 / VCAM-1交互抗原识别增强b细胞活化这个函数似乎是独立的是最后的边缘定位。

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