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首页> 外文期刊>Behavioural neurology >Apathy in Parkinson's disease: Diagnosis, neuropsychological correlates, pathophysiology and treatment
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Apathy in Parkinson's disease: Diagnosis, neuropsychological correlates, pathophysiology and treatment

机译：帕金森氏病的冷漠：诊断，神经心理学，病理生理学和治疗

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摘要

Apathy has been defined as lack of motivation. It has been traditionally considered as a symptom of psychiatric disorders, such as major depression and schizophrenia, but more recently it has been recognized as a specific neuropsychiatric syndrome associated with neurodegenerative such as Parkinson's disease (PD). As a consequence the reported prevalence of apathy in PD ranges from 13.9% to 70%; the mean prevalence is 35%. Prevalence of ?pure apathy? (i.e., of apathy without comorbid depression and dementia) seems to be substantially lower, from 3 to 47.9%. High levels of apathy in PD are associated with decreased daily function, specific cognitive deficits and increased stress for families. Although neuroimaging studies do not provide a unique anatomic pattern, several data suggest that the ventromedial prefrontal cortex and the basal ganglia connected through frontal-subcortical circuits, are particularly involved in the genesis of apathy. At present, there are no approved medications for the treatment of apathy in and no proof of efficacy exists for any drug in current use. Further studies and innovative pharmacologic approaches are thus needed to ameliorate our understanding and treatment of apathy in PD.
机译：冷漠已被定义为缺乏动力。传统上，它被认为是精神疾病的症状，例如严重的抑郁症和精神分裂症，但是最近，它被认为是与神经退行性疾病如帕金森氏病（PD）相关的特定神经精神病综合症。结果，据报道PD中冷漠的患病率在13.9％至70％之间。平均患病率为35％。纯粹冷漠的患病率（即无并发抑郁和痴呆的冷漠）从3％降至47.9％。 PD的冷漠程度与日常功能下降，特定的认知缺陷和家庭压力增加有关。尽管神经影像学研究并未提供独特的解剖学模式，但一些数据表明，通过额叶皮层下回路连接的腹侧前额叶皮层和基底神经节特别参与了冷漠的发生。目前，尚无批准的用于治疗冷漠的药物，并且目前使用的任何药物均没有疗效证据。因此，需要进一步的研究和创新的药理方法，以改善我们对PD冷漠的理解和治疗。

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