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首页> 外文期刊>Hepatology research: the official journal of the Japan Society of Hepatology >Wisteria floribunda Wisteria floribunda agglutinin positive human Mac‐2‐binding protein as a predictor of hepatocellular carcinoma development in chronic hepatitis C patients
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Wisteria floribunda Wisteria floribunda agglutinin positive human Mac‐2‐binding protein as a predictor of hepatocellular carcinoma development in chronic hepatitis C patients

机译：紫藤花束月季紫藤多花植物凝集素积极的人类Mac 2量结合蛋白肝细胞癌发展的预测在慢性丙型肝炎患者

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Aims Wisteria floribunda agglutinin (WFA)‐positive human Mac‐2‐binding protein (WFA + ‐M2BP) is a new glycol marker related to liver fibrosis. The aim of the present study was to evaluate WFA + ‐M2BP as a predictor of hepatocellular carcinoma (HCC) development in patients with chronic hepatitis C. Methods This case–control study included 14 patients with chronic hepatitis C who developed HCC and 52controls, matched for age, gender, and fibrosis stage. WFA + ‐M2BP was measured at biopsy and follow‐up. Time zero was set at the date of liver biopsy. Results WFA + ‐M2BP increased stepwise with progression of liver fibrosis (p 0.001). Cumulative incidence of HCC development was significantly higher in patients with WFA + ‐M2BP ≥4.2 (p 0.001) or in those with time‐course changes in WFA + ‐M2BP (ΔWFA + ‐M2BP/year) ≥0.3 (p = 0.03). Multivariate analyses demonstrated that WFA + ‐M2BP ≥4.2 [hazard ratio (HR): 4.1, 95% confidence interval (CI): 1.1–15, p = 0.04], ΔWFA + ‐M2BP/year ≥0.3 (HR: 5.5, 95% CI: 1.5–19, p = 0.008), and AFP ≥10 ng/ml (HR: 4.7, 95% CI: 1.1–19, p = 0.03) were independent predictive factors of HCC development. Based on these data, we developed a simple scoring system to predict HCC development using these three factors. Using these scores, patients were classified into four groups; cumulative incidence of HCC development significantly increased with increasing scores (p 0.001). Conclusions WFA + ‐M2BP measurements and time‐course changes in WFA + ‐M2BP can be used to identify patients at high risk of HCC development. Real‐time monitoring of WFA + ‐M2BP can be a novel predictor of HCC development.
机译：目标是紫藤多花植物凝集素(WFA)阳性人类Mac量2量结合蛋白(WFA +必经M2BP)是一个新的乙二醇标记与肝纤维化有关。本研究的目的是评估WFA +量M2BP预测肝细胞癌慢性患者(HCC)发展丙型肝炎病例对照研究方法包括14慢性丙型肝炎患者肝癌和52控制发展,年龄匹配,性别和纤维化阶段。以活检和遵循。设置日期的肝脏活检。M2BP逐步增加与进展肝纤维化(p & 肝细胞癌的发病率显著发展高患者WFA +量M2BP≥4.2 (p & 0.001)或者在那些随着时间的变化WFA +必经M2BP(ΔWFA +必经M2BP /年)≥0.3 (p = 0.03)。多变量分析表明,WFA +量M2BP≥4.2(风险比(人力资源):4.1,95%可信区间(CI): -15年1.1,p = 0.04),ΔWFA≥大于0.3 adjusted +‐M2BP / year (HR: 550, 95% CI: 1.5个烷基19,p =0.008),法新社≥10 ng / ml(人力资源:4.7,95%置信区间CI:-19年1.1,p = 0.03)独立的预测肝癌发展的因素。我们开发了一个简单的评分系统预测肝细胞癌发展使用这三个因素。这些分数,患者分为四组织;与增加得分显著增加(p& 地理和时间过程的变化WFA + M2BP应承担的用于识别肝癌的高危患者发展。可以是一个小说肝癌发展的预测。

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