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首页> 外文期刊>Hepatology research: the official journal of the Japan Society of Hepatology >Iron chelation prevents lung injury after major hepatectomy.
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Iron chelation prevents lung injury after major hepatectomy.

机译：铁螯合后防止肺损伤主要肝切除术。

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Aim: Oxidative stress has been implicated in lung injury following ischemia/reperfusion and resection of the liver. We tested whether alleviating oxidative stress with iron chelation could improve lung injury after extended hepatectomy. Methods: Twelve adult female pigs subjected to liver ischemia for 150 min, 65-70% hepatectomy and reperfusion of the remnant liver for 24 h were randomized to a desferrioxamine (DF) group (n = 6) which received i.v. desferrioxamine to a total dose of 100 mg/kg during both ischemia and reperfusion, and a control (C) group (n = 6). We recorded hemodynamic and respiratory parameters, plasma interleukin-6 and malondialdehyde levels, as well as liver malondialdehyde and protein carbonyls content. Total non-heme iron was measured in lung and liver. Pulmonary tissue was evaluated histologically for its nitrotyrosine and protein carbonyls content and for superoxide dismutase (SOD) and platelet-activating factor acetylhydrolase (PAF-AcH) activities. Results: Reperfusion of the remnant liver resulted in gradual deterioration of gas-exchange and pulmonary vascular abnormalities. Iron chelation significantly decreased the oxidative markers in plasma, liver and the lung and lowered activities of pulmonary SOD and PAF-AcH. The improved liver function was followed by improved arterial oxygenation and pulmonary vascular resistance. DF also improved alveolar collapse and inflammatory cell infiltration, while serum interleukin-6 increased. Conclusion: In an experimental pig model that combines liver resection with prolonged ischemia, iron chelation during reperfusion of the remnant liver is associated with improvement of several parameters of oxidative stress, lung injury and arterial oxygenation.
机译：目的:氧化应激已经涉及到肺受伤后缺血/再灌注切除的肝脏。减轻氧化应激与铁螯合延长后可以改善肺损伤吗肝切除术。接受肝脏缺血150分钟,65 - 70%肝切除术和残余肝脏再灌注24 h desferrioxamine被随机分配(DF)组(n = 6)接受注射。desferrioxamine总剂量为100毫克/公斤在缺血和再灌注,控制(C)组(n = 6)。我们的记录血流动力学和呼吸参数、等离子体白细胞介素- 6和丙二醛水平作为肝丙二醛羰基和蛋白质内容。和肝脏。组织学检查为其硝基酪氨酸和蛋白质羰基含量和超氧化物歧化酶(SOD)和platelet-activating因素acetylhydrolase (PAF-AcH)活动。再灌注的残余肝脏导致气体交换和逐渐恶化肺血管异常。显著降低氧化标记血浆、肝、肺和降低活动肺SOD和PAF-AcH。功能是改善动脉紧随其后氧化和肺血管阻力。也改善肺泡塌陷和炎症细胞渗透,而血清白细胞介素- 6增加了。模型,结合肝切除长时间的缺血,铁螯合期间再灌注的残余肝脏有关与改进的几个参数氧化应激,肺损伤和动脉氧化。

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