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首页> 外文期刊>Hepatology research: the official journal of the Japan Society of Hepatology >Metabolic changes of anterior cingulate cortex in patients with hepatic cirrhosis: A magnetic resonance spectroscopy study.
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Metabolic changes of anterior cingulate cortex in patients with hepatic cirrhosis: A magnetic resonance spectroscopy study.

机译：前扣带皮层的代谢变化肝硬化患者:一个磁场磁共振光谱学研究。

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Aim: The anterior cingulate cortex (ACC) plays an important role in cognitive functions. The purpose of this study is to compare metabolite concentrations in the ACC of cirrhotic patients with normal controls, and to correlate metabolite changes with Child-Pugh class and with severity of hepatic encephalopathy (HE). Methods: Fifty-two cirrhotic patients and 30 healthy volunteers were included in this study. All subjects performed the number connection test type A (NCT-A) and digital symbol test (DST) before multiple resonance (MR) examinations. Single-voxel proton MR spectroscopy (MRS) data in the ACC were acquired on a 1.5-T scanner. The ratios of all metabolites to creatine and phosphocreatine (Cr) were obtained. Statistical analysis was performed to evaluate the difference between control and cirrhotic patients, with respect to metabolite ratios. The correlation between metabolite ratios and Child-Pugh scale, severity of HE, venous ammonia and neuropsychiatric test results was analyzed. Results: The ratios of choline (Cho)/Cr and myo-inositol (mIns)/Cr were significantly lower, and the ratio of glutamine- glutamate (Glx)/Cr was significantly higher in cirrhotic patients than those in controls (P < 0.001). mIns/Cr correlated negatively with Child-Pugh scale (r = -0.496, P < 0.001) and HE degree (r = -0.313, P < 0.05). Venous ammonia had a significant correlation with Cho/Cr (r = -0.329, P < 0.05) and mIns/Cr (r = -0.347, P < 0.05). No statistical correlation between metabolite ratios and neuropsychological tests was found for cirrhotic patients, but mIns/Cr did have a statistical correlation with NCT-A (r = -0.270, P < 0.05) and DST (r = 0.463, P < 0.001) when all subjects were included in the analysis. Conclusion: Significant metabolite changes were seen in the ACC in cirrhotic patients. Of the metabolites examined, the mIns/Cr level in the ACC was most closely associated with the severity of HE and hepatic functional reserve reflected by Child-Pugh scale.
机译：目的:前扣带皮层(ACC)扮演认知功能的重要作用。本研究的目的是比较代谢物ACC浓度的肝硬化患者与正常对照组和关联代谢物变化与儿童类和严重性肝性脑病(他)。52肝硬化患者和30名健康志愿者被纳入本研究。对象执行连接测试数量A型(NCT-A)和数字符号测试(DST)在多个磁共振(MR)考试。Single-voxel质子光谱先生(太太)的数据ACC上获得1.5 - t扫描仪。肌酸和比率的代谢物磷酸肌酸(Cr)。分析评估的区别控制和肝硬化患者之间,对代谢物比率。代谢物之间的比率和儿童的规模,他的严重性,静脉氨和神经精神病学的测试结果进行了分析。结果:胆碱(Cho) / Cr的比率肌醇(分钟)/ Cr显著降低,谷氨酸和谷氨酰胺的比例——(Glx) / Cr肝硬化患者的风险高吗比控制(P < 0.001)。与儿童规模负相关(r =-0.496, P < 0.001)和他度(r = -0.313, P <0.05)。相关性与曹/ Cr (r = -0.329, P < 0.05)和分钟/ Cr (r = -0.347, P < 0.05)。代谢物之间的统计相关性比率和神经心理学测试被发现肝硬化患者,但分钟/ Cr确实有与NCT-A统计相关性(r = -0.270, P< 0.05)和DST (r = 0.463, P < 0.001)受试者包括在分析中。结论:巨大的代谢物变化ACC肝硬化患者。代谢物检查,分钟/ Cr水平ACC最严重程度密切相关他和肝储备功能的体现儿童的规模。

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