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首页> 外文期刊>The EMBO journal. >Present and not reporting for duty: dsRNAi in mammalian cells
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Present and not reporting for duty: dsRNAi in mammalian cells

机译：现在和没有报道:dsRNAi哺乳动物细胞

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摘要

Double-stranded RNA interference (dsRNAi) represents a primary means of anti-viral defense in plants, worms, and insects, yet appears mostly supplanted bythe protein-based interferon (IFN) response in vertebrates such as mammals. The degree to which dsRNAi is anti-viral in mammals has been contentious. Maillard etal () find that dsRNAi retains sequence-specific silencing in mammalian cells incapable of triggering an IFN response, suggesting that dsRNAi is inhibited by the action of interferon-stimulated genes. Importantly, they observe that while dsRNA can vaccinate against the incoming cognate virus though dsRNAi silencing, no dsRNAi is observed with viral infection alone, suggesting that this evolutionarily conserved anti-viral pathway is present but functionally elusive in the cell types studied thus far.
机译：双链RNA干扰(dsRNAi)代表一个抗病毒防御的主要手段在植物、蠕虫和昆虫,然而大多出现取代阻止蛋白质干扰素(IFN)在脊椎动物,如哺乳动物的反应。程度dsRNAi抗病毒在哺乳动物一直有争议。dsRNAi保留sequence-specific沉默哺乳动物细胞无法触发一个干扰素响应,表明dsRNAi受到抑制干扰素刺激基因的作用。重要的是,他们观察到,虽然极对传入的同源病毒接种疫苗虽然dsRNAi沉默,没有dsRNAi观察与病毒感染,表明这一点进化保守抗病毒通路但在细胞功能难以捉摸类型研究迄今为止。

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