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首页> 外文期刊>The EMBO journal. >Sororin actively maintains sister chromatid cohesion
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Sororin actively maintains sister chromatid cohesion

机译：Sororin积极维护姐妹染色单体凝聚力

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Cohesion between sister chromatids is established during DNA replication but needs to be maintained to enable proper chromosome-spindle attachments in mitosis or meiosis. Cohesion is mediated by cohesin, but also depends on cohesin acetylation and sororin. Sororin contributes to cohesion by stabilizing cohesin on DNA. Sororin achieves this by inhibiting WAPL, which otherwise releases cohesin from DNA and destroys cohesion. Here we describe mouse models which enable the controlled depletion of sororin by gene deletion or auxin-induced degradation. We show that sororin is essential for embryonic development, cohesion maintenance, and proper chromosome segregation. We further show that the acetyltransferases ESCO1 and ESCO2 are essential for stabilizing cohesin on chromatin, that their only function in this process is to acetylate cohesin's SMC3 subunit, and that DNA replication is also required for stable cohesin-chromatin interactions. Unexpectedly, we find that sororin interacts dynamically with the cohesin complexes it stabilizes. This implies that sororin recruitment to cohesin does not depend on the DNA replication machinery or process itself, but on a property that cohesin acquires during cohesion establishment.
机译：建立姐妹染色单体之间的凝聚力在DNA复制,但需要维护启用适当chromosome-spindle附件在有丝分裂或减数分裂。cohesin,还取决于cohesin乙酰化作用和sororin。稳定cohesin DNA。通过抑制WAPL,否则释放cohesin从DNA和破坏凝聚力。描述小鼠模型,使控制sororin基因缺失或损耗auxin-induced退化。对胚胎发育至关重要,凝聚力维护和适当的染色体隔离。我们进一步表明,乙酰转移酶ESCO1和ESCO2对于稳定cohesin至关重要染色质,他们唯一的功能过程是乙醯化cohesin SMC3亚基,DNA复制,也需要稳定cohesin-chromatin交互。出乎意料地,我们发现sororin交互动态与cohesin复合物稳定。cohesin并不依赖于DNA复制机械或过程本身,而是一个属性期间cohesin获得凝聚力建立。

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