The Cdk5-p35 kinase,associates with the Golgi apparatus and regulates membrane traffic

Paglini G; Peris L; Diez-Guerra JQuiroga SCaceres A

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The Cdk5-p35 kinase,associates with the Golgi apparatus and regulates membrane traffic

机译：与高尔基Cdk5-p35激酶,同事装置和调节膜流量

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We show here that an active Cdk5-p35 kinase is present in Golgi membranes, where it associates with a detergent-insoluble fraction containing actin. In addition, Cdk5-p35-dependent phosphorylation of alpha -PAK immunoreactive protein species was detected in Golgi membranes, as well as an interaction with the small GTPase, Cdc42. Moreover, antisense oligonucleotide suppression of Cdk5 or p35 in young cultured neurons, as well as inhibition of Cdk5 activity with olomoucine, blocks the formation of membrane vesicles from the Golgi apparatus. Taken together, these results show a novel subcellular localization of this kinase and suggest a role for Cdk5-p35 in membrane traffic during neuronal process, outgrowth.

机译：我们这里展示积极Cdk5-p35激酶在高尔基体膜,同事包含detergent-insoluble分数肌动蛋白。磷酸化的αpak免疫反应性的蛋白质的物种被发现在高尔基体膜,以及与小GTPase的交互,Cdc42。抑制Cdk5 p35区域或年轻的培养神经元,以及抑制Cdk5活动与olomoucine块膜的形成从高尔基体小泡。在一起,这些结果显示一个新颖的亚细胞本地化的激酶和建议作用在神经元膜Cdk5-p35的交通过程中,副产物。

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来源
《EMBO Journal》 |2001年第12期|1139-1144|共6页
作者
Paglini G; Peris L; Diez-Guerra JQuiroga SCaceres A;
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作者单位

Caceres A, INIMEC, CONICET, Ave Friuli 2334, RA-5016 Cordoba, Argentina;

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原文格式 PDF
正文语种英语
中图分类分子生物学;
关键词
Activators; Protein; Membrane vesiclesNeuronsEffectorsolomoucinePathwayKinaseCyclin-Dependent Kinase 5Membrane Protein TrafficActin CytoskeletonCDK-Activating Kinase Assembly Factor MAT1Golgi Apparatus;

机译：活化剂;蛋白质;膜vesiclesNeuronsEffecto;

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机译：CDK5-P35激酶与GOLGI装置相关联并调节膜交通

The Cdk5-p35 kinase,associates with the Golgi apparatus and regulates membrane traffic

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