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首页> 外文期刊>Applied Microbiology and Biotechnology >Genomic analysis of Brevibacillus thermoruber 423 reveals its biotechnological and industrial potential
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Genomic analysis of Brevibacillus thermoruber 423 reveals its biotechnological and industrial potential

机译：短杆菌423的基因组分析揭示了其生物技术和工业潜力

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摘要

Brevibacillus thermoruber 423 is a Gram-positive, motile, red-pigmented, spore-forming, aerobic, and thermophilic bacterium that is known to produce high levels of exopolysaccharide (EPS) with many potential uses in food, feed, cosmetics, and pharmaceutical and chemical industries. This bacterium not only is among the limited number of reported thermophilic EPS producers but also exceeds other thermophilic producers in light of the high level of polymer synthesis. By a systems-based approach, whole-genome analysis of this bacterium was performed to gain more insight about the biological mechanisms and whole-genome organization of thermophilic EPS producers and hence to develop rational strategies for the genetic and metabolic optimization of EPS production. Also with this study, the first genome analysis was performed on a thermophilic Brevibacillus species. Essential genes associated with EPS biosynthesis were detected by genome annotation, and together with experimental evidences, a hypothetical mechanism for EPS biosynthesis was generated. B. thermoruber 423 was found to have many potential applications in biotechnology and industry because of its capacity to utilize xylose and to produce EPS, isoprenoids, ethanol/butanol, lipases, proteases, cellulase, and glucoamylase enzymes as well as its resistance to arsenic.
机译：短杆菌热橡胶423是革兰氏阳性，活动性，红色色素，孢子形成，需氧和嗜热细菌，已知会产生高水平的胞外多糖（EPS），在食品，饲料，化妆品，药​​品和化学工业。考虑到聚合物合成的高水平，该细菌不仅是报道的嗜热EPS产生剂的有限数目，而且超过了其他嗜热性产生剂。通过基于系统的方法，对该细菌进行了全基因组分析，以获取有关嗜热EPS产生者的生物学机制和全基因组组织的更多见解，从而为EPS产生的遗传和代谢优化开发合理的策略。同样通过这项研究，首次对嗜热短杆菌属物种进行了基因组分析。通过基因组注释检测与EPS生物合成相关的必需基因，并与实验证据一起，生成了EPS生物合成的假设机制。发现热芽孢杆菌423由于其利用木糖和产生EPS，类异戊二烯，乙醇/丁醇，脂肪酶，蛋白酶，纤维素酶和葡糖淀粉酶的能力以及其对砷的抗性而在生物技术和工业中具有许多潜在的应用。

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