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Burkholderia: an update on taxonomy and biotechnological potential as antibiotic producers

机译：伯克霍尔德氏菌：作为抗生素生产者的生物分类学和生物技术潜力的最新进展

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摘要

Burkholderia is an incredibly diverse and versatile Gram-negative genus, within which over 80 species have been formally named and multiple other genotypic groups likely represent new species. Phylogenetic analysis based on the 16S rRNA gene sequence and core genome ribosomal multilocus sequence typing analysis indicates the presence of at least three major clades within the genus. Biotechnologically, Burkholderia are well-known for their bioremediation and biopesticidal properties. Within this review, we explore the ability of Burkholderia to synthesise a wide range of antimicrobial compounds ranging from historically characterised antifungals to recently described antibacterial antibiotics with activity against multiresistant clinical pathogens. The production of multiple Burkholderia antibiotics is controlled by quorum sensing and examples of quorum sensing pathways found across the genus are discussed. The capacity for antibiotic biosynthesis and secondary metabolism encoded within Burkholderia genomes is also evaluated. Overall, Burkholderia demonstrate significant biotechnological potential as a source of novel antibiotics and bioactive secondary metabolites.
机译：伯克霍尔德氏菌是一个极为多样且用途广泛的革兰氏阴性菌，其中已有80多个物种被正式命名，其他多个基因型群体可能代表了新物种。基于16S rRNA基因序列和核心基因组核糖体多基因座序列类型分析的系统发育分析表明，该属中至少存在三个主要进化枝。在生物技术上，伯克霍尔德氏菌以其生物修复和生物杀虫特性而闻名。在这篇综述中，我们探讨了伯克霍尔德氏菌合成多种抗菌化合物的能力，从历史上具有特征的抗真菌药到最近描述的对多药耐药的临床病原体具有活性的抗菌素。通过群体感应来控制多种伯克霍尔德菌抗生素的产生，并讨论在整个属中发现的群体感应途径的例子。还评估了伯克霍尔德菌基因组内编码的抗生素生物合成和二次代谢的能力。总体而言，伯克霍尔德菌显示出巨大的生物技术潜力，可以作为新型抗生素和生物活性次生代谢物的来源。

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