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首页> 外文期刊>Applied Microbiology and Biotechnology >A small molecule norspermidine in combination with silver ion enhances dispersal and disinfection of multi-species wastewater biofilms
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A small molecule norspermidine in combination with silver ion enhances dispersal and disinfection of multi-species wastewater biofilms

机译：小分子鸟精m与银离子结合可增强多物种废水生物膜的分散和消毒

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Detrimental biofilms have become a great concern in many areas due to their strong resistance and insensitivity to traditional antimicrobial agents. Norspermidine is a potent small molecule for biofilm dispersal. In this study, silver ion, a conventional inorganic biocide, was combined with norspermidine and used for control and removal of multi-species biofilms formed by a mixed culture from wastewater treatment systems. Results showed that silver ion (0.01-1 mg/L) treatment alone failed to remove the existing wastewater biofilms. Norspermidine at the concentrations of 500-1000 mu M was capable to disrupt and disperse the existing biofilms with a biofilm reduction of 21-34 % after 24-h exposure. The combined treatment with norspermidine (500 mu M) and silver ion (0.01 mg/L) increased biofilm reduction to 48 % (24-h exposure). The combined treatment also enhanced biofilm disinfection ratio (82 %, 2-h exposure) by 2.0- and 2.6-folds compared to norspermidine (27 %) or silver ion (23 %) treatment alone, respectively. Confocal laser scanning microscopic (CLSM) observations found that norspermidine could disrupt biofilm matrix and promote biofilm dispersal via breaking down exopolysaccharides. The combined treatment increased the reduction in biofilm cell density and viability, possibly due to the damage of biofilm matrix, enhanced silver ion diffusion in biofilms, and increased biofilm sensitivity. These findings indicate that the combination of a small molecule norspermidine with a traditional biocide silver ion presents a novel strategy to remove and kill biofilms, which have a potential application in addressing wastewater biofilm-related issues.
机译：由于其对传统抗菌剂的强抵抗力和不敏感性，有害生物膜已成为许多领域的关注重点。去甲精是生物膜分散的有效小分子。在这项研究中，将银离子（一种常规的无机杀生物剂）与降鸟精结合，并用于控制和去除废水处理系统中混合培养形成的多种生物膜。结果表明，仅银离子（0.01-1 mg / L）处理无法去除现有的废水生物膜。在暴露24小时后，浓度为500-1000μM的去甲精胺能够破坏和分散现有的生物膜，生物膜减少量为21-34％。降鸟精idine（500μM）和银离子（0.01 mg / L）的联合处理将生物膜减少量增加到48％（24小时暴露）。与单独的鸟精胺（27％）或银离子（23％）处理相比，组合处理还分别将生物膜消毒率（82％，暴露2小时）提高了2.0倍和2.6倍。共聚焦激光扫描显微镜（CLSM）观察发现，去甲精idine可通过分解胞外多糖破坏生物膜基质并促进生物膜扩散。联合处理增加了生物膜细胞密度和活力的降低，这可能是由于生物膜基质的损伤，生物膜中银离子扩散的增强以及生物膜敏感性的提高。这些发现表明，小分子降鸟精m与传统杀生物剂银离子的结合提出了一种新的去除和杀死生物膜的策略，这在解决废水生物膜相关问题方面具有潜在的应用价值。

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