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Biotechnology of non-Saccharomyces yeasts-the basidiomycetes

机译:非酿酒酵母酵母的生物技术

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Yeasts are the major producer of biotechnology products worldwide, exceeding production in capacity and economic revenues of other groups of industrial microorganisms. Yeasts have wide-ranging fundamental and industrial importance in scientific, food, medical, and agricultural disciplines (Fig. 1). Saccharomyces is the most important genus of yeast from fundamental and applied perspectives and has been expansively studied. Non-Saccharomyces yeasts (nonconventional yeasts) including members of the Ascomycetes and Basidiomycetes also have substantial current utility and potential applicability in biotechnology. In an earlier minireview, "Biotechnology of non-Saccharomyces yeasts-the ascomycetes" (Johnson Appl Microb Biotechnol 97: 503–517, 2013), the extensive biotechnological utility and potential of ascomycetous yeasts are described. Ascomycetous yeasts are particularly important in food and ethanol formation, production of single-cell protein, feeds and fodder, heterologous production of proteins and enzymes, and as model and fundamental organisms for the delineation of genes and their function in mammalian and human metabolism and disease processes. In contrast, the roles of basidiomycetous yeasts in biotechnology have mainly been evaluated only in the past few decades and compared to the ascomycetous yeasts currently have limited industrial utility. From a biotechnology perspective, the basidiomycetous yeasts are known mainly for the production of enzymes used in pharmaceutical and chemical synthesis, for production of certain classes of primary and secondary metabolites such as terpenoids and carotenoids, for aerobic catabolism of complex carbon sources, and for bioremediation of environmental pollutants and xenotoxicants. Notwithstanding, the basidiomycetous yeasts appear to have considerable potential in biotechnology owing to their catabolic utilities, formation of enzymes acting on recalcitrant substrates, and through the production of unique primary and secondary metabolites. This and the earlier mini-review (Johnson Appl Microb Biotechnol 97:503–517, 2013) were motivated during the preparation and publication of the landmark three-volume set of "The yeasts: a taxonomic study, 5th edition" (Kurtzman et al. 2011a, b).
机译:酵母菌是全球生物技术产品的主要生产者,其产量和经济收入超过了其他种类的工业微生物。酵母在科学,食品,医学和农业学科中具有广泛的基础和工业重要性(图1)。从基础和应用的观点来看,酵母是酵母最重要的属,并且已经被广泛地研究。包括子囊菌和担子菌属的成员的非酿酒酵母(非常规酵母)在生物技术中也具有相当大的当前实用性和潜在适用性。在较早的小型综述中,“非酿酒酵母酵母的生物技术-子囊菌”(Johnson Appl Microb Biotechnol 97:503–517,2013)描述了子囊酵母的广泛的生物技术实用性和潜力。子囊酵母在食物和乙醇的形成,单细胞蛋白质的生产,饲料和饲料,蛋白质和酶的异源生产以及作为模型和基础生物的基因和微生物在人类和人类新陈代谢和疾病中的功能方面特别重要流程。相比之下,担子菌酵母在生物技术中的作用仅在过去的几十年中才得到主要评估,并且与目前工业用途有限的子囊酵母相比。从生物技术的角度来看,担子菌酵母主要用于生产用于药物和化学合成的酶,用于生产某些类型的一级和二级代谢产物(如萜类和类胡萝卜素),用于复杂碳源的需氧分解代谢以及用于生物修复。的环境污染物和异种毒素。尽管如此,由于担子菌的分解代谢作用,作用于顽re底物的酶的形成以及独特的一级和二级代谢产物的产生,在生物技术中似乎具有相当大的潜力。这份和之前的小型综述(Johnson Appl Microb Biotechnol 97:503–517,2013)是在准备并出版具有里程碑意义的三卷集“酵母:分类学研究,第5版”(Kurtzman等人, 2011a,b)。

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