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首页> 外文期刊>Lung cancer: Journal of the International Association for the Study of Lung Cancer >Histologic prognostic factors for small-sized squamous cell carcinomas of the peripheral lung.
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Histologic prognostic factors for small-sized squamous cell carcinomas of the peripheral lung.

机译：小型的组织学预后因素肺鳞状细胞癌的外围。

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摘要

OBJECTIVE: Although the incidence of peripheral squamous cell carcinomas (SqCCs) of the lung has increased over recent years, histologic prognostic factors for small peripheral SqCCs have not been well established. The aim of this study is to identify clinicopathologic prognostic factors. MATERIALS AND METHODS: We evaluated various clinicopathologic parameters in 101 patients with peripheral lung SqCCs (defined as tumors located in or more peripheral to the fourth branching bronchus), measuring 6 tumor cells), small (2-5 tumor cells) or single cell. The 5-year disease-free survival rate was significantly worse in patients with single cell nests (50 patients, 69.5%) than in those with small nests (42 patients, 94.1%) (P = 0.0035, log rank test). TheMTN size had a significant impact on survival in patients with pathologic stage IA disease and tumors < or = 20 mm in diameter. A background of UIP, which correlated with the presence of a single cell invasive component and pleural involvement, was also a poor prognostic factor, suggesting that peripheral SqCC in UIP is highly malignant even if the tumor is small. CONCLUSION: The MTN size is a useful prognostic factor for small peripheral SqCCs. Tumors with a single cell invasive component appear to be highly malignant, and should be distinguished from invasive cancers with a low malignant potential (tumors with large or small tumor nest components).
机译：目的:尽管外围的发病率肺鳞状细胞癌(SqCCs)近年来,增加组织学对小型外围SqCCs预后因素尚未建立。研究是确定临床病理的预后的因素。101年各种临床病理的参数患者外周肺SqCCs(定义为肿瘤位于或更多的外围第四分支支气管),测量 6肿瘤细胞),小(2 - 5肿瘤细胞)或单个细胞。无病生存率显著更糟糕的是在单个细胞巢患者(50例,69.5%)比那些小巢(42例,94.1%)(P = 0.0035,日志等级测试)。TheMTN大小对生存产生重大影响IA疾病和患者的病理阶段肿瘤直径<或= 20毫米。摘要,与存在单个细胞入侵组件和胸膜参与,也是一个可怜的预后因子,表明外围SqCC摘要高度恶性肿瘤,即使很小。MTN的大小是一个有用的预后因素小SqCCs外围。侵入性组件似乎高度恶性,,应该区别于侵入性癌症与较低的潜在恶性肿瘤(大或小瘤巢组件)。

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