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首页> 外文期刊>Applied neuropsychology. Adult >Loss of semantic associative categories in patients with Alzheimer's disease.
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Loss of semantic associative categories in patients with Alzheimer's disease.

机译：阿尔茨海默氏病患者的语义联想类别丧失。

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摘要

Deterioration of semantic memory is one of the primary neuropsychological deficits caused by Alzheimer's disease (AD). In this study, we hypothesize that the breakdown of semantic memory in the mild-to-moderate stage of AD is due to the disruption of the semantic network that links the concepts. Furthermore, the loss of these links is not homogeneous through the semantic association categories (i.e., Superordinate, Contiguity, Part/Whole, Attribute, Function). Twenty-two subjects (11 patients with mild-to-moderate dementia and 11 control subjects matched on demographics) participated in the study. Both controls and patients with AD underwent extensive neuropsychological evaluation and three experimental tasks: (1) Naming Task, (2) Semantic Association Task, and (3) Semantic Knowledge Task. Results showed that: (1) The AD group was significantly different from the normal controls group in all the experimental tasks; (2) the Semantic Association Task was significantly worse than the other tasks; (3) for the AD group, the scores of the Function and Part/Whole association categories were higher than in the other categories; and (4) living stimuli were more impaired than nonliving. These data confirm prior research showing the semantic association is differently impaired in AD patients.
机译：语义记忆的恶化是由阿尔茨海默氏病（AD）引起的主要神经心理学缺陷之一。在这项研究中，我们假设在AD的轻度到中度阶段，语义记忆的崩溃是由于链接概念的语义网络的中断引起的。此外，通过语义关联类别（即，上级，连续性，部分/整体，属性，功能），这些链接的丢失不是同质的。 22名受试者（11名轻度至中度痴呆患者和11名对照受试者在人口统计学上相符）参加了研究。对照组和患有AD的患者均接受了广泛的神经心理学评估和三个实验任务：（1）命名任务，（2）语义联想任务和（3）语义知识任务。结果表明：（1）AD组在所有实验任务上均与正常对照组明显不同; （2）语义联想任务明显比其他任务差; （3）对于AD组，“功能”和“零件/整体关联”类别的得分高于其他类别; （4）生活刺激比非生活受到的损害更大。这些数据证实了先前的研究表明在AD患者中语义关联受到了不同的损害。

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