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首页> 外文期刊>EMBO Journal >THE INTERLEUKIN-7 RECEPTOR ALPHA CHAIN TRANSMITS DISTINCT SIGNALS FOR PROLIFERATION AND DIFFERENTIATION DURING B LYMPHOPOIESIS
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THE INTERLEUKIN-7 RECEPTOR ALPHA CHAIN TRANSMITS DISTINCT SIGNALS FOR PROLIFERATION AND DIFFERENTIATION DURING B LYMPHOPOIESIS

机译：白介素受体α链传送不同的扩散和信号在B淋巴细胞增殖分化

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摘要

The interleukin 7 receptor (IL7R), which contains a unique alpha chain and a gamma chain shared by other cytokine receptors, is indispensable for normal lymphocyte development. The basis for this role is poorly understood. Here we show that the IL7R alpha chain not only causes progenitors to proliferate, but also has a distinct activity in inducing differentiation. First, we identify a single cytoplasmic tyrosine residue in the IL7R alpha chain that is essential for cell cycle entry and proliferation dependent on phosphatidylinositol 3-kinase. We use a mutant alpha chain in which this residue has been altered to reconstitute B lymphopoiesis by retrovirus-mediated gene transfer in cultures of bone marrow from mice deficient in IL7R alpha chain. The mutation abrogates the proliferation of B-lymphocyte progenitors, but reveals a novel function of the alpha chain in promoting immunoglobulin heavy chain gene rearrangement leading to B-cell differentiation. This function is lost (but proliferation sustained) when the cytoplasmic domain of IL7R alpha is replaced by corresponding sequences from the IL2R, despite the similarity in their signalling mechanisms. Thus, the signals which mediate a differentiative function of the IL7R in B lymphopoiesis are specific and distinct from those causing proliferation.
机译：白介素7受体(IL7R),其中包含一个独特的α链和γ链共享其他细胞因子受体,是必不可少的淋巴细胞的正常发展。角色是知之甚少。IL7Rα链不仅会导致祖细胞增殖,但也有不同的活动诱导分化。单胞质IL7R酪氨酸残基α链对细胞周期至关重要入口和扩散的依赖磷脂酰肌醇3-kinase。这种残留的α链改变重组B淋巴细胞增殖在文化retrovirus-mediated基因转移从小鼠骨髓缺乏IL7Rα链。淋巴球祖细胞,但揭示了小说在促进α链的功能免疫球蛋白重链基因重排导致b细胞分化。时失去了(但持续增殖)胞质域IL7Rα取代了从IL2R相应序列,尽管相似的信号机制。因此,信号调节细胞分化函数的IL7R B淋巴细胞增殖具体的,不同于那些导致扩散。

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