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首页> 外文期刊>Applied immunohistochemistry and molecular morphology: AIMM >Impact of progesterone receptor semiquantitative immunohistochemical result on oncotype DX recurrence score: A quality assurance study of 1074 cases
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Impact of progesterone receptor semiquantitative immunohistochemical result on oncotype DX recurrence score: A quality assurance study of 1074 cases

机译：孕激素受体半定量免疫组化结果对肿瘤型DX复发评分的影响：一项1074例质量保证研究

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摘要

Decreased or absent progesterone receptor expression in invasive breast carcinoma is a marker for an adverse prognosis. As part of an ongoing quality assurance study, this study evaluated the relationship between Oncotype DX recurrence score and progesterone receptor immunohistochemical result within each Nottingham tumor grade in 1074 cases of invasive breast carcinoma for which an Oncotype DX recurrence score was available. In addition to a statistically significant association between Nottingham grade and Oncotype DX recurrence score categories (P<0.001), an inverse relationship was identified between progesterone receptor expression measured by modified H-score semiquantitation and Oncotype DX recurrence score that was independent of Nottingham tumor grade. The Oncotype DX recurrence score relies heavily on parameters already available from routine pathologic examination, and consideration of progesterone receptor status may aid in selection of patients most likely to benefit from ancillary testing.
机译：浸润性乳腺癌中孕激素受体表达降低或缺失是不良预后的标志。作为一项正在进行的质量保证研究的一部分，该研究评估了1074例浸润性乳腺癌中Oncotype DX复发评分均可用的诺丁汉肿瘤等级内Oncotype DX复发评分与孕激素受体免疫组化结果之间的关系。除了诺丁汉等级与Oncotype DX复发评分类别之间的统计学显着相关性（P <0.001）外，还确定了通过改良的H分数半定量测量的孕激素受体表达与独立于诺丁汉肿瘤等级的Oncotype DX复发评分之间存在反比关系。 。 Oncotype DX复发评分严重依赖于常规病理学检查中已有的参数，考虑孕激素受体状态可能有助于选择最有可能从辅助检查中受益的患者。

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