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首页> 外文期刊>Blood purification >Hemoperfusion with an immobilized polymyxin B column reduces the blood level of neutrophil elastase.
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Hemoperfusion with an immobilized polymyxin B column reduces the blood level of neutrophil elastase.

机译：固定化多粘菌素B柱进行血液灌注会降低中性粒细胞弹性蛋白酶的血液水平。

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BACKGROUND: We investigated whether direct hemoperfusion with an immobilized polymyxin B column (DHP with PMX) could reduce the blood level of neutrophil elastase. METHODS: 20 sepsis patients were enrolled in the study. DHP with PMX was performed twice within a 24-hour period. Neutrophil elastase was measured 7 times. RESULTS: Neutrophil elastase was 468 +/- 75.1 microg/l, while it was 1,531 +/- 201.7 microg/l immediately after the first session, declined to 351 +/- 73.9 microg/l before the second session of DHP with PMX, and increased again to 599.3 +/- 112.7 microg/l immediately after the second session, 328 +/- 73.7 microg/l at 24 h, 264 +/- 39.3 microg/l at 48 h, and 230 +/- 36.1 microg/l at 72 h after DHP with PMX. The levels from 48 h onwards were significantly lower compared with that before treatment. CONCLUSION: DHP with PMX has an overall effect that reduces circulating neutrophil elastase levels.
机译：背景：我们研究了使用固定化多粘菌素B柱（DHP和PMX）直接进行血液灌流是否可以降低中性粒细胞弹性蛋白酶的血液水平。方法：20例脓毒症患者入选本研究。 DMX和PMX在24小时内执行了两次。测量中性粒细胞弹性蛋白酶7次。结果：中性粒细胞弹性蛋白酶为468 +/- 75.1 microg / l，而在第一疗程后立即为1,531 +/- 201.7 microg / l，在第二疗程的DHP和PMX疗程前下降至351 +/- 73.9 microg / l，并在第二次治疗后立即再次增加至599.3 +/- 112.7微克/升，24小时为328 +/- 73.7微克/升，48小时为264 +/- 39.3微克/升和230 +/- 36.1微克/升l在使用DMX进行DHP后72小时。与治疗前相比，从48小时开始的水平显着降低。结论：DHP与PMX具有降低循环中性粒细胞弹性蛋白酶水平的总体作用。

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