A switch in a substrate tunnel for directing regioselectivity of nitrile hydratases towards alpha,omega-dinitriles

Cheng Zhongyi; Cui Wenjing; Liu ZhongmeiZhou LiWang MinKobayashi MichihikoZhou Zhemin

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A switch in a substrate tunnel for directing regioselectivity of nitrile hydratases towards alpha,omega-dinitriles

机译：开关在衬底对指导隧道区域选择性的腈水合酶

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摘要

The beta 37 residue of nitrile hydratase (NHase) from Pseudomonas putida and NHase from Comamonas testosteroni played a critical role in directing enzyme regioselectivity. Amino acid substitution in this site modulated or even inverted enzyme regioselectivity towards aliphatic alpha,omega-dinitriles.

机译：腈水合酶的β37残渣(NHase)从假单胞菌putida并从Comamonas NHasetestosteroni指导中发挥了至关重要的作用酶区域选择性。在这个网站调制甚至倒酶区域选择性对脂肪族α,omega-dinitriles。

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来源
《Catalysis science & technology》 |2016年第5期|1292-1296|共5页
作者
Cheng Zhongyi; Cui Wenjing; Liu ZhongmeiZhou LiWang MinKobayashi MichihikoZhou Zhemin;
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作者单位

Tianjin Univ Sci & Technol, Coll Biotechnol, 29 13th St TEDA, Tianjin 300457, Peoples R China;

Jiangnan Univ, Sch Biotechnol, Key Lab Ind Biotechnol, Minist Educ, Wuxi 214122, Peoples R China;

Univ Tsukuba, Inst Appl Biochem, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058572, Japan;

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正文语种英语
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nitrilase; Switches; Amino Acid SubstitutionEnzymesComamonas testosteroniPseudomonas putidatunnel;

机译：腈水解酶;交换机;氨基酸SubstitutionEnzymesComamonastestosteroniPseudomonas putidatunnel;

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A switch in a substrate tunnel for directing regioselectivity of nitrile hydratases towards alpha,omega-dinitriles

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