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首页> 外文期刊>Chemical Engineering Research & Design: Transactions of the Institution of Chemical Engineers >Surface functionalization of SBA-15 nanorods for anticancer drug delivery
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Surface functionalization of SBA-15 nanorods for anticancer drug delivery

机译：SBA-15表面功能化的纳米棒抗癌药物输送

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摘要

SBA-15 nanorods with high surface area (1010 m~2 g~(-1)) were functionalized by post grafting method with three different alkoxysilanes including (3-aminopropyl) triethoxysilane (APTES), 3-[bis(2-hydroxyethyl)amino] propyl tri-ethoxysilane (HAPS) and 3-[2-(2-aminoethylamino) ethylamino] propyl trimethoxysilane (AEPS). The prepared materials were used as nanocarriers for an anticancer drug (gemcitabine). The obtained samples were characterized by SAXS, elemental analysis, TGA, N2 adsorption/desorption, SEM, TEM, FTIR and UV spectroscopies. The adsorption and release properties of all samples were investigated. It was found that the surface functionalization increases the interaction between the carrier and gemcitabine and results in the loading enhancement of the drug. In addition, the adsorption of gemcitabine on the modified mesoporous matrix depends on the type and the amount of alkoxysilanes groups. The maximum content of the deposited drug in the modified SBA-15 nanorods is close to 22 wt.%. The rate of the drug release from the modified samples containing NH2 groups on their surfaces is pH dependent.
机译：SBA-15纳米棒具有高表面积(1010 m ~ 2g ~(1))被嫁接后功能化方法和三种不同的alkoxysilanes包括triethoxysilane (3-aminopropyl)APTES), 3 -[直到(2-hydroxyethyl) amino] propyltri-ethoxysilane(也许不久)3 - (2 - (2-aminoethylamino) ethylamino)丙基trimethoxysilane (aep)。作为一种抗癌药物的人们吗(吉西他滨)。以粉煤灰、元素分析、热重分析,N2吸附紫外线/ desorption闪、TEM、FTIR and光谱学。所有被调查样本的属性。发现表面功能化吗增加载体和之间的交互吉西他滨在加载和结果增强的药物。吸附吉西他滨的修改取决于类型和介孔矩阵alkoxysilanes组。内容存放药物的修改SBA-15纳米棒接近22 wt. %。修改后的样品的药物释放包含氨基组的表面是pH值相关的。

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