LAG-3 and PD-1 blockade raises the bar for melanoma

Caroline Robert

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LAG-3 and PD-1 blockade raises the bar for melanoma

机译：LAG-3和PD-1封锁了酒吧黑素瘤

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Combination of approved immune checkpoint inhibitors has shown remarkable efficacy in the treatment of melanoma, but at the cost of high toxicity. After years of intensive research, inhibitors of the immune checkpoint molecule LAG-3 are now demonstrating promising results and favorable toxicity profiles in clinical trials in combination with inhibition of the checkpoint molecule PD-1.

机译：通过免疫检查点的组合抑制剂已经显示出显著的功效治疗黑色素瘤,但成本高毒性。抑制剂免疫检查点的分子LAG-3现在展示了有前景的结果有利的毒性资料在临床试验中结合抑制的检查站分子PD-1。

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来源
《Nature cancer.》 |2021年第12期|1251-1253|共3页
作者
Caroline Robert;
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作者单位

Department of Medicine, Dermatology Service, Gustave Roussy and Paris-Saclay University, INSERM;

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原文格式 PDF
正文语种英语
中图分类
关键词
Melanoma; Checkpoints; Cell Cycle CheckpointsClinical TrialPDCD1 geneTreatment EffectivenessImmunity;

机译：黑色素瘤,检查点;细胞周期CheckpointsClinical TrialPDCD1 geneTreatmentEffectivenessImmunity;

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专利

1. Identification ACTA2 and KDR as key proteins for prognosis of PD-1/PD-L1 blockade therapy in melanoma [J] . Yuchen Wang, Zhaojun Li, Zhihui Zhang, 动物模型与实验医学（英文） . 2021,第002期
2. Identification ACTA2 and KDR as key proteins for prognosis of PD- 1/PD- L1 blockade therapy in melanoma [J] . Yuchen Wang, Zhaojun Li, Zhihui Zhang, 动物模型与实验医学（英文） . 2021,第002期
3. PD-L1, PD-1, LAG-3, and TIM-3 in Melanoma: Expression in Brain Metastases Compared to Corresponding Extracranial Tumors [J] . Jaeyun Jane Wang, Peter Burger, Janis Taube, Cureus. . 2019,第12期

机译：Melanoma中的PD-L1，PD-1，LAG-3和TIM-3：与相应的颅外肿瘤相比脑转移中的表达
4. LAG-3 and PD-1+LAG-3 inhibition promote anti-tumor immune responses in human autologous melanoma/T cell co-cultures [J] . Nicolas Gestermann, Damien Saugy, Christophe Martignier, Oncoimmunology. . 2020,第1期

机译：LAG-3和PD-1 + LAG-3抑制促进人自体黑色素瘤/ T细胞共培养中的抗肿瘤免疫应答
5. Expression of LAG‐3 and efficacy of combination treatment with anti‐LAG‐3 and anti‐PD‐1 monoclonal antibodies in glioblastoma [J] . Harris‐Bookman Sarah, Mathios Dimitrios, Martin Allison M., International Journal of Cancer =: Journal International du Cancer . 2018,第12期

机译：LAG-3的表达及抗LAG-3和抗PD-1单克隆抗体在胶质母细胞瘤中的疗效
6. (S1·37-S019)LiNbO_3 における{1_-bar 21-bar 0}/<101-bar 0>小傾角粒界の転位構造 [C] . 中村篤智, 中村惇之介, 岸田逸平日本金属学会大会 . 2011

机译：（S1·37-S019）{1_-bar 21-bar 0} / <101-bar 0> / <101-bar 0> LINBO_3中的减法角晶界限
7. Expression and Function of Co-inhibitory Receptors PD-1, TIGIT, TIM-3, and LAG-3 in Systemic Sclerosis [D] . Fleury, Michelle. 2018

机译：共抑制性受体PD-1，TIGIT，TIM-3和LAG-3在系统性硬化中的表达和功能
8. LAG-3 and PD-1+LAG-3 inhibition promote anti-tumor immune responses in human autologous melanoma/T cell co-cultures [O] . Nicolas Gestermann, Damien Saugy, Christophe Martignier, 2020

机译：LAG-3和PD-1 + LAG-3抑制促进人体自体黑色素瘤/ T细胞共培养中的抗肿瘤免疫应答
9. PD-L1, PD-1, LAG-3, and TIM-3 in Melanoma: Expression in Brain Metastases Compared to Corresponding Extracranial Tumors [O] . Jaeyun Jane Wang, Peter Burger, Janis Taube, 2019

机译：Melanoma中的PD-L1，PD-1，LAG-3和TIM-3：与相应的颅外肿瘤相比脑转移中的表达
10. Measurements of the Decays B0->D0bar pp bar, B0->D0pp bar, B0->D-pp bar/pi+, and B0->D-pp bar/pi+ [R] . Aubert, B. 2006

机译：衰变测量B0-> D0bar pp bar，B0-> D0pp bar，B0-> D-pp bar / pi +，和B0-> D-pp bar / pi +

LAG-3 and PD-1 blockade raises the bar for melanoma

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