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首页> 外文期刊>Journal of Cellular Physiology >HOTAIR role in melanoma progression and its identification in the blood of patients with advanced disease
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HOTAIR role in melanoma progression and its identification in the blood of patients with advanced disease

机译：在黑素瘤进展及其热空气的作用识别患者的血液中先进的疾病

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The molecular mechanisms responsible for the metastatic progression of melanoma have not been fully defined yet. We have recently shown that an important role in this process is certainly played by HOX genes, whose regulation is under control of particular non-coding RNAs, some of which are present within the HOX locus. HOTAIR is the most studied among them, whose aberrant expression is associated with the metastatic progression of many malignancies. The aim of this study was to verify the role played by HOTAIR in metastatic progression of melanoma and to evaluate the circulating levels of HOTAIR in the blood of patients with metastatic melanoma. A series of melanocytic lesions were selected to evaluate the potential changes in the expression of HOTAIR during the evolution of the disease through in situ and molecular approaches. None of the benign melanocytic lesions showed the presence of HOTAIR. The staining of HOTAIR resulted very weak in the primary pT1 lesions, while it was very strong in all pairs of primary tissues and corresponding metastases. Surprisingly, we found the presence of HOTAIR in some intratumoral lymphocytes, while this positivity decreased in lymphocyte component further away from the tumor. HOTAIR was also detected in the serum of selected metastatic patients. These data allowed us to speculate on the fundamental role played by HOTAIR in tumor evolution of melanoma. Its presence in intratumoral lymphocytes might suggest that its involvement in the modulation of tumor microenvironment and the detection in the serum could be used in the management of melanoma patients.
机译：负责的分子机制转移性黑色素瘤没有进展完全定义。在这一过程中重要作用是肯定的由HOX基因的监管之下控制特定的非编码rna,一些现在在HOX轨迹。其中研究最多的,其异常表达式与转移相关许多恶性肿瘤的进展。研究验证热空气中所扮演的角色转移性黑色素瘤的发展评估的热空气循环水平转移性黑色素瘤患者的血液。一系列melanocytic病变被挑选评估潜在的变化表达式热空气在疾病的发展通过原位和分子的方法。良性melanocytic病变显示热空气的存在。导致病变,主要pT1很弱虽然它是在所有成对的主要很强组织和相应的转移。令人惊讶的是,我们发现热空气的存在一些瘤内淋巴细胞,而这一点积极性减少淋巴细胞组件远离肿瘤。检测血清中选定的转移病人。基本热空气在肿瘤所扮演的角色黑色素瘤的进化。瘤内淋巴细胞可能意味着它参与肿瘤的调制微环境和血清的检测可用于黑色素瘤的管理病人。

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