Long noncoding RNAs (lncRNAs) in triple negative breast cancer

Wang Qiuhong; Gao Sheng; Li HaiboLv MingmingLu Cheng

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Long noncoding RNAs (lncRNAs) in triple negative breast cancer

机译：长非编码rna (lncRNAs)三重阴性乳腺癌

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Long noncoding RNAs (lncRNAs) are dysregulated in many cancer types, which are believed to play crucial roles in regulating several hallmarks of cancer biology. Triple Negative Breast Cancer (TNBC) is a very aggressive subtype of normal breast cancer, which has features of negativity for ER, PR, and HER2. Great efforts have been made to identify an association between lncRNAs expression profiles and TNBC, and to understand the functional role and molecular mechanism on aberrant- expressed lncRNAs. In this review, we summarized the existed knowledge on the systematics, biology, and function of lncRNAs. The advances from the most recent studies of lncRNAs in the predicament of breast cancer, TNBC, are highlighted, especially the functions of specifically selected lncRNAs. Wealso discussed the potential value of these lncRNAs in TNBC, providing clues for the diagnosis and treatments of TNBC.

机译：长非编码rna (lncRNAs)中特异表达许多癌症类型,据信玩至关重要的作用在调节的几个特点癌症生物学。(TNBC)是一个非常积极的亚型正常乳腺癌,消极的特性ER、PR和HER2。识别lncRNAs之间的关联表达谱和TNBC,理解功能的作用和分子机制异常——lncRNAs表示。总结了存在的知识lncRNAs的分类学、生物学和功能。从最近的研究进展lncRNAs在乳腺癌的困境,TNBC突出显示,尤其是函数具体的选择lncRNAs。讨论了这些lncRNAs的潜在价值TNBC,为诊断和提供线索TNBC的治疗。

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来源
《Journal of Cellular Physiology》 |2017年第12期|3226-3233|共8页
作者
Wang Qiuhong; Gao Sheng; Li HaiboLv MingmingLu Cheng;
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作者单位

Nantong Univ, Dept Clin Lab, Nantong Maternal & Child Hlth Care Hosp, Nantong, Peoples R China;

Nanjing Med Univ, Obstet & Gynecol Hosp, Nanjing Maternal & Child Hlth Hosp, Dept Breast, 123;

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正文语种英语
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关键词
Dilemma; Taxonomy; Long Intergenic Non-Protein Coding RNAHallmarkingbreasts normalTriple Negative Breast NeoplasmsCancer BiologyBreast Cancer;

机译：基因间非蛋白困境;分类;长编码RNAHallmarkingbreasts normalTriple消极的乳房NeoplasmsCancer BiologyBreast癌症;

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Long noncoding RNAs (lncRNAs) in triple negative breast cancer

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