Unique Regulatory Mechanisms for the Human Embryonic Stem Cell Cycle

Vanoudenhove Jennifer J.; Grandy Rodrigo A.; Ghule Prachi N.Lian Jane B.Stein Janet L.Zaidi Sayyed K.Stein Gary S.

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Unique Regulatory Mechanisms for the Human Embryonic Stem Cell Cycle

机译：人类独特的监管机制胚胎干细胞细胞周期

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The cell cycle in pluripotent human embryonic stem cells is governed by unique mechanisms that support unrestricted proliferation and competency for endodermal, mesodermal, and ectodermal differentiation. The abbreviated G1 period with retention of uncompromised fidelity for genetic and epigenetic mechanisms operative in control of proliferation support competency for expansion of the pluripotent cell population that is fundamental for initial stages of development. Regulatory events during the G1 period of the pluripotent cell cycle are decisive for the transition from pluripotency to lineage commitment. Recent findings indicate that a G2 cell cycle pause is present in both endodermal and mesodermal lineage cells, and is obligatory for differentiation to endoderm. (C) 2016 Wiley Periodicals, Inc.

机译：人类胚胎干细胞多能性的细胞周期细胞是由独特的机制支持无限制的增殖和能力内胚层、中胚层和外胚层的分化。保留遗传的不妥协的忠诚和表观遗传机制的控制增殖能力扩张的支持的多能细胞群基本的初始发展阶段。在G1期的监管活动多能细胞周期是决定性的从血统的多能性的承诺。细胞周期暂停内胚层的存在和中胚层细胞谱系,必修课内胚层分化。期刊、公司。

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《Journal of Cellular Physiology》 |2017年第6期|1254-1257|共4页
作者
Vanoudenhove Jennifer J.; Grandy Rodrigo A.; Ghule Prachi N.Lian Jane B.Stein Janet L.Zaidi Sayyed K.Stein Gary S.;
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Univ Vermont, Coll Med, Dept Biochem, 89 Beaumont Ave, Burlington, VT 05405 USA;

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正文语种英语
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关键词
Human Embryonic Stem Cells; Cell Cycle; Developmental stagescell populationcompetencepluripotencyRegulatoryEctodermal DifferentiationdescentUnique;

机译：人类胚胎干细胞;细胞发展stagescell周期;

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1. Growth differentiation factor 6,a repressive target of EZH2,promotes the commitment of human embryonic stem cells to mesenchymal stem cells [J] . Pend Deng, Yongxin Yu, Christine Hong, 骨研究：英文 . 2020,第004期
2. Growth differentiation factor 6, a repressive target of EZH2, promotes the commitment of human embryonic stem cells to mesenchymal stem cells [J] . Pend Deng, Yongxin Yu, Christine Hong, 骨研究（英文版） . 2020,第004期
3. The similarity between human embryonic stem cell-derived epithelial cells and ameloblast-lineage cells [J] . Li-Wei Zheng, Logan Linthicum, Pamela K DenBesten, 国际口腔科学杂志（英文版） . 2013,第001期
4. Adu; Aged;; Aged, 80 and over;; Cadherins;; Carcinoma, Squamous Cell;; Cell Nucleus;; Cytoplasm;; Female;; Humans;; Laryngeal Neoplasms;; Male;; Middle Aged;; Neoplasm Staging;; Protein-Serine-Threonine Kinases;; Proto-Oncogene Proteins c-akt;; Retrospective Studies;; beta Catenin;; *成年人;; 老年人;; 老年人, 80以上;; 钙粘着糖蛋白类;; 癌, 鳞状细胞;; 细胞核;; 细胞质;; 喉肿瘤;; 肿瘤分期;; 蛋白质丝氨酸苏氨酸激酶;; 回顾性研究 [J] . Acta Anaesthesiologica Scandinavica . 2009,第10期

机译：Adu; Aged;; Aged, 80 and over;; Cadherins;; Carcinoma, Squamous Cell;; Cell Nucleus;; Cytoplasm;; Female;; Humans;; Laryngeal Neoplasms;; Male;; Middle Aged;; Neoplasm Staging;; Protein-Serine-Threonine Kinases;; Proto-Oncogene Proteins c-akt;; Retrospective Studies;; beta Catenin;; *成年人;; 老年人;; 老年人, 80以上;; 钙粘着糖蛋白类;; 癌, 鳞状细胞;; 细胞核;; 细胞质;; 喉肿瘤;; 肿瘤分期;; 蛋白质丝氨酸苏氨酸激酶;; 回顾性研究
5. Transposable Element Mediated Innovation in Gene Regulatory Landscapes of Cells: Re鈥怴isiting the 鈥淕ene鈥怋attery鈥?Model [J] . Sundaram Vasavi, Wang Ting BioEssays : . 2018,第1期

机译：Transposable Element Mediated Innovation in Gene Regulatory Landscapes of Cells: Re鈥怴isiting the 鈥淕ene鈥怋attery鈥?Model
6. Reconstitution of gene expression from a regulatory-protein-deficient hepatitis B virus genome by cell-permeable HBx protein [J] . Hafner A, Brandenburg B, Hildt E EMBO Journal . 2003,第8期

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7. Advances in STEM-CELL. A Free Software for TEM and STEM Analysis and Simulations: Probe Deconvolution in STEM-HAADF [C] . V.Grillo International Metallographic Society Annual meeting;Microscopy Society of America Annual Meeting;Microanalysis Society Annual meeting . 2011

机译：STEM-CELL的进展。用于TEM和STEM分析和仿真的免费软件：STEM-HAADF中的探针反卷积
8. Erratum to Ponassi R et al. Cell Cycle Volume 7 Issue 20; pp. 3211-24 [O] . Raffaella Ponassi, Barbara Biasotti, Valeria Tomati, 2012

机译：对Ponassi R等人的勘误。 Cell Cycle Volume 7Issue 20;第3211-24页
9. Mechanisms underlying the self-renewal characteristic and cardiac differentiation of mouse embryonic stem cells. [O] . 2009

机译：mechanisms underlying the self-renewal characteristic and cardiac differentiation of mouse embryonic stem cells.

Unique Regulatory Mechanisms for the Human Embryonic Stem Cell Cycle

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