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首页> 外文期刊>Journal of Cellular Physiology >DC-STAMP: A Key Regulator in Osteoclast Differentiation
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DC-STAMP: A Key Regulator in Osteoclast Differentiation

机译：DC-STAMP:破骨细胞的关键调节器分化

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Osteoimmunology research is a new emerging research field that investigates the links between the bone and immune responses. Results from osteoimmunology studies suggest that bone is not only an essential component of the musculoskeletal system, but is also actively involved in immune regulation. Many important factors involved in immune regulation also participate in bone homeostasis. Bone homeostasis is achieved by a coordinated action between bone-synthesizing osteoblasts and bone-degrading osteoclasts. An imbalanced action between osteoblasts and osteoclasts often results in pathological bone diseases: osteoporosis is caused by an excessive osteoclast activity, whereas osteopetrosis results from an increased osteoblast activity. This review focuses on dendritic cell-specific transmembrane protein (DC-STAMP), an important protein currently considered as a master regulator of osteoclastogenesis. Of clinical relevance, the frequency of circulating DC-STAMP_cells is elevated during the pathogenesis of psoriatic diseases. Intriguingly, recent results suggest that DC-STAMP also plays an imperative role in bone homeostasis by regulating the differentiation of both osteoclasts and osteoblasts. This article summarizes our current knowledge on DC-STAMP by focusing on its interacting proteins, its regulation on osteoclastogenesis-related genes, its possible involvement in immunoreceptor tyrosine-based inhibitory motif (ITIM)-mediated signaling cascade, and its potential of developing therapeutics for clinical applications. (C) 2016 Wiley Periodicals, Inc.
机译：近年来的研究是一个新的新兴研究领域,调查的链接骨头和免疫反应之间的关系。从近年来的研究表明,骨不仅是一个重要的组成部分肌肉骨骼系统,但也积极参与免疫调节。因素也参与免疫调节参与骨内稳态。是通过之间的协调行动造骨细胞和骨bone-synthesizing bone-degrading破骨细胞。成骨细胞和破骨细胞往往导致骨骼疾病病理:骨质疏松过度造成的破骨细胞活动,而骨硬化病增加的结果成骨细胞活动。树突特异性跨膜蛋白(DC-STAMP),目前一个重要的蛋白质视为一个主监管机构osteoclastogenesis。循环DC-STAMP_cells频率高架在银屑病的发病机制疾病。DC-STAMP也起着必要的作用骨内稳态的调节破骨细胞的分化造骨细胞。知识DC-STAMP通过专注于其相互作用的蛋白质,其监管osteoclastogenesis-related基因,它的可能参与immunoreceptor tyrosine-based抑制主题(ITIM)介导的信号级联,其发展的潜力疗法的临床应用。威利期刊公司。

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