Peripheral Blood Mononuclear Cells Spontaneous Osteoclastogenesis: Mechanisms Driving the Process and Clinical Relevance in Skeletal Disease

Salamanna Francesca; Maglio Melania; Borsari VeronicaGiavaresi GianlucaAldini Nicolo NicoliFini Milena

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Peripheral Blood Mononuclear Cells Spontaneous Osteoclastogenesis: Mechanisms Driving the Process and Clinical Relevance in Skeletal Disease

机译：外周血单核细胞自发的Osteoclastogenesis:驱动机制过程和临床相关性骨骼疾病

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In vitro peripheral blood mononuclear cells differentiate into osteoclasts under the influence of osteoclast-stimulating factors. However, accumulating evidence suggests spontaneous osteoclasts formation and activity in patients affected by local or systemic bone remodeling diseases in comparison with healthy controls. Therefore, within this review, we summarize the studies where spontaneous osteoclastogenesis of peripheral blood mononuclear cells was observed in pathological conditions of the skeletal system. We indicate a linkage between immunoregulation by T cells and spontaneous osteoclasts formation with increased levels of tumor necrosis factors-, receptor activator of nuclear factor kappa-B ligand and inteleukin-7 production. In the light of these results, it would be of crucial importance to deepen the correlation between systemic bone remodeling diseases and spontaneous osteoclastogenesis as well as to investigate in detail the mechanisms underlying this phenomenon and the clinical relevance in bone remodeling disease diagnosis and monitoring. J. Cell. Physiol. 231: 521-530, 2016. (c) 2015 Wiley Periodicals, Inc.

机译：体外外周血单核细胞下分化为破骨细胞osteoclast-stimulating因素的影响。然而,越来越多的证据表明自发的破骨细胞形成和活动病人受到局部或全身性骨骼的影响重塑疾病与健康相比控制。总结研究自发的osteoclastogenesis的外周血单核细胞在病理观察骨骼系统的条件。之间的联系通过T细胞和免疫调节自发破骨细胞形成和增加水平的肿瘤坏死因子、受体核因子kappa-B配体和催化剂inteleukin-7生产。结果,将是至关重要的深化系统性骨之间的相关性重塑疾病和自发的osteoclastogenesis以及调查详细的机制这一现象和骨重建的临床意义疾病的诊断和监测。杂志。231:521 - 530年,2016年。期刊、公司。

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《Journal of Cellular Physiology》 |2016年第3期|521-530|共10页
作者
Salamanna Francesca; Maglio Melania; Borsari VeronicaGiavaresi GianlucaAldini Nicolo NicoliFini Milena;
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作者单位

Rizzoli Ortopaed Inst, Rizzoli Res Innovat Technol Dept, Lab Biocompatibil Technol Innovat & Adv;

Rizzoli Ortopaed Inst, Lab Preclin & Surg Studies, I-40136 Bologna, Italy;

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正文语种英语
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关键词
Disease diagnosis; Immunoregulation; OsteoclastOsteoclastogenesisImmunomodulationSkeleton, diseaseSpontaneousperipheral blood mononuclear cellSkeletal systembone fusionsNF-kappa B;

机译：疾病诊断、免疫调节、OsteoclastOsteo;

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Peripheral Blood Mononuclear Cells Spontaneous Osteoclastogenesis: Mechanisms Driving the Process and Clinical Relevance in Skeletal Disease

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