• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Cellular Physiology >Tumor Microenvironment Versus Cancer Stem Cells in Cholangiocarcinoma: Synergistic Effects?
【24h】

Tumor Microenvironment Versus Cancer Stem Cells in Cholangiocarcinoma: Synergistic Effects?

机译：肿瘤微环境与肿瘤干细胞胆管癌:协同效应?

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Cholangiocarcinoma (CCAs) may be defined as tumors that derived from the biliary tree with the differentiation in the biliary epithelial cells. This tumor is malignant, extremely aggressive with a poor prognosis. It can be treated surgically and its pathogenesis is poorly understood. The tumor microenvironment (TME) is a very important factor in the regulation of tumor angiogenesis, invasion, and metastasis. Besides cancer stem cells (CSCs) can modulate tumor growth, stroma formation, and migratory capability. The initial stage of tumorigenesis is characterized by genetic mutations and epigenetic alterations due to intrinsic factors which lead to the generation of oncogenes thus inducing tumorigenesis. CSCs may result from precancerous stem cells, cell de-differentiation, normal stem cells, or an epithelial-mesenchymal transition (EMT). CSCs have been found in the cancer niche, and EMT may occur early within the tumor microenvironment. Previous studies have demonstrated evidence of cholangiocarcinoma stem cells (CD133, CD24, EpCAM, CD44, and others) and the presence of these markers has been associated with malignant potential. The interaction between TME and cholangiocarcinoma stem cells via signaling mediators may create an environment that accommodates tumor growth, yielding resistance to cytotoxic insults (chemotherarapeutic). While progress has been made in the understanding of the mechanisms, the interactions in the tumorigenic process still remain a major challenge. Our review, addresses recent concepts of TME-CSCs interaction and will emphasize the importance of early detection with the use of novel diagnostic mechanisms such as CCA-CSC biomarkers and the importance of tumor stroma to define new treatments. (C) 2015 Wiley Periodicals, Inc.
机译：胆管癌(cca)可以定义为肿瘤源于胆道树的在胆道上皮细胞分化。这个肿瘤是恶性的,非常积极预后不良。手术,其发病机制不佳理解。肿瘤的规定的非常重要的因素血管生成、入侵和转移。癌症干细胞(二者)可以调节肿瘤增长、基质形成和迁移能力。基因变异和表观遗传的特征改变由于内在因素导致致癌基因的生成从而诱导肿瘤发生。干细胞,细胞de-differentiation,正常的干细胞细胞,或一个epithelial-mesenchymal过渡(EMT)。和EMT可能在肿瘤发生早期微环境。显示胆管癌干细胞的证据细胞(CD133, CD24 EpCAM, CD44,和其他人)这些标记的存在有关恶性潜能。通过时间和胆管癌干细胞信号介质可能创造一个环境适应肿瘤生长、屈服抗细胞毒性的侮辱(chemotherarapeutic)。理解的机制,相互作用在肿瘤发生的过程仍然是一个重大的挑战。最近的概念TME-CSCs交互和意志强调早期诊断的重要性使用新颖的诊断等机制CCA-CSC生物标志物和肿瘤的重要性基质来定义新的治疗方法。期刊、公司。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号