Cell Surface Human Airway Trypsin-Like Protease Is Lost During Squamous Cell Carcinogenesis

Duhaime Michael J.; Page Khaliph O.; Varela Fausto A.Murray Andrew S.Silverman Michael E.Zoratti Gina L.List Karin

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Cell Surface Human Airway Trypsin-Like Protease Is Lost During Squamous Cell Carcinogenesis

机译：细胞表面人工气道Trypsin-Like蛋白酶失去了在鳞状细胞癌形成

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Cancer progression is accompanied by increased levels of extracellular proteases that are capable of remodeling the extracellular matrix, as well as cleaving and activating growth factors and receptors that are involved in pro-cancerous signaling pathways. Several members of the type II transmembrane serine protease (TTSP) family have been shown to play critical roles in cancer progression, however, the expression or function of the TTSP Human Airway Trypsin-like protease (HAT) in carcinogenesis has not been examined. In the present study we aimed to determine the expression of HAT during squamous cell carcinogenesis. HAT transcript is present in several tissues containing stratified squamous epithelium and decreased expression is observed in carcinomas. We determined that HAT protein is consistently expressed on the cell surface in suprabasal/apical layers of squamous cells in healthy cervical and esophageal epithelia. To assess whether HAT protein is differentially expressed in normal tissue versus tissue in different stages of carcinogenesis, we performed a comprehensive immunohistochemical analysis of HAT protein expression levels and localization in arrays of paraffin embedded human cervical and esophageal carcinomas compared to the corresponding normal tissue. We found that HAT protein is expressed in the non-proliferating, differentiated cellular strata and is lost during the dedifferentiation of epithelial cells, a hallmark of squamous cell carcinogenesis. Thus, HAT expression may potentially be useful as a marker for clinical grading and assessment of patient prognosis in squamous cell carcinomas. J. Cell. Physiol. 231: 1476-1483, 2016. (c) 2015 Wiley Periodicals, Inc.

机译：癌症进展伴随着增加胞外蛋白酶的水平重塑细胞外基质的能力,裂开和激活生长因子和受体参与pro-cancerous信号通路。2跨膜丝氨酸蛋白酶(TTSP)的家庭已被证明在癌症?扮演关键角色然而,过程或函数的表达式TTSP人类呼吸道Trypsin-like蛋白酶(帽子)致癌作用尚未研究。本研究旨在确定在鳞状细胞表达的帽子致癌作用。几个包含复层扁平的组织上皮和减少表达式在癌。持续表达在细胞表面suprabasal /顶端鳞状细胞层健康的宫颈和食管上皮细胞。评估是否帽子蛋白质是不同的正常组织中表达和组织致癌作用的不同阶段,我们执行一个全面的免疫组织化学分析帽子蛋白表达水平和本地化数组的人类宫颈癌和石蜡包埋食管癌相比相应的正常组织。、蛋白表达,分化细胞层中丢失上皮细胞的去分化鳞状细胞癌形成的标志。帽子可能是有用的作为一个表达式标记为临床分级和评估在鳞状细胞癌患者预后。细胞。威利期刊公司。

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来源
《Journal of Cellular Physiology》 |2016年第7期|1476-1483|共8页
作者
Duhaime Michael J.; Page Khaliph O.; Varela Fausto A.Murray Andrew S.Silverman Michael E.Zoratti Gina L.List Karin;
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作者单位

Barbara Ann Karmanos Canc Inst, Detroit, MI USA;

Wayne State Univ, Sch Med, Dept Pharmacol, Detroit, MI USA;

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原文格式 PDF
正文语种英语
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关键词
Proteases; Tissues; Tumor ProgressionGrowth FactorsSquamous Epithelial Cellspatient's prognosisCell SurfaceCarcinogenesisHistone AcetyltransferasesStratified Squamous EpitheliumCarcinoma;

机译：ProgressionGrowth蛋白酶;组织;肿瘤FactorsSquamous上皮Cellspatient的prognosisCell SurfaceCarcinogenesisHistoneAcetyltransferasesStratified鳞状;

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机译：Adu; Aged;; Aged, 80 and over;; Cadherins;; Carcinoma, Squamous Cell;; Cell Nucleus;; Cytoplasm;; Female;; Humans;; Laryngeal Neoplasms;; Male;; Middle Aged;; Neoplasm Staging;; Protein-Serine-Threonine Kinases;; Proto-Oncogene Proteins c-akt;; Retrospective Studies;; beta Catenin;; *成年人;; 老年人;; 老年人, 80以上;; 钙粘着糖蛋白类;; 癌, 鳞状细胞;; 细胞核;; 细胞质;; 喉肿瘤;; 肿瘤分期;; 蛋白质丝氨酸苏氨酸激酶;; 回顾性研究
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机译：molecular conservation of estrogen-response associated with cell cycle regulation, hormonal carcinogenesis and cancer in zebrafish and human cancer cell lines

Cell Surface Human Airway Trypsin-Like Protease Is Lost During Squamous Cell Carcinogenesis

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