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首页> 外文期刊>Journal of Cellular Physiology >Derivation of Endodermal Progenitors From Pluripotent Stem Cells
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Derivation of Endodermal Progenitors From Pluripotent Stem Cells

机译：来源的内皮祖细胞多能干细胞

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摘要

Gastrulation, the step that follows blastula formation during development, consists of the separation of the three embryonic germ layers, namely ectoderm, endoderm and mesoderm. Vertebrate animal models have revealed highly conserved mechanisms of endoderm morphogenesis and determination (Kimelman and Griffin, 2000; Grapin-Botton and Constam, 2007). Following establishment of the endoderm, complex morphogenetic movements and crosstalk with mesodermal tissues lead to an endodermal gut tube with an established anterior-posterior (AP) axis and several progenitor domains that will give rise to the parenchyma of endodermal organs (thyroid, lung, pancreas, liver, gastrointestinal (Gl) tract). Although our understanding of endodermal differentiation has greatly advanced in recent years (Zorn and Wells, 2009), several gaps in our knowledge remain concerning the specification of endodermal progenitors.
机译：原肠胚形成,接下来的步骤囊胚在开发过程中形成的,包括分离的三个胚胎胚芽层,即外胚层、内胚层、中胚层。脊椎动物模型揭示了高度守恒的内胚层形态发生机制和决心(Kimelman和格里芬,2000;Grapin-Botton Constam, 2007)。建立内胚层,复杂形态形成运动和相声中胚层组织导致内胚层的肠道管建立了一个前后(美联社)轴和几个给祖域内胚层的器官的实质(甲状腺、肺、胰腺、肝脏、胃肠(Gl)束)。内胚层的差异化极大地先进近年来(左恩和威尔斯,2009),几个我们掌握的知识还存在很大欠缺有关内皮祖细胞的规范。

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