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首页> 外文期刊>Journal of Cellular Physiology >Bmp2 Deletion Causes an Amelogenesis Imperfecta Phenotype Via Regulating Enamel Gene Expression
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Bmp2 Deletion Causes an Amelogenesis Imperfecta Phenotype Via Regulating Enamel Gene Expression

机译：Bmp2删除导致釉质发生天空”通过调节搪瓷基因表达表型

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Although Bmp2 is essential for tooth formation, the role of Bmp2 during enamel formation remains unknown in vivo. In this study, the role of Bmp2 in regulation of enamel formation was investigated by the Bmp2 conditional knock out (Bmp2 cKO) mice. Teeth of Bmp2 cKO mice displayed severe and profound phenotypes with asymmetric and misshaped incisors as well as abrasion of incisors and molars. Scanning electron microscopy analysis showed that the enamel layer was hypoplastic and enamel lacked a typical prismatic pattern. Teeth from null mice were much more brittle as tested by shear and compressive moduli. Expression of enamel matrix protein genes, amelogenin, enamelin, and enamel-processing proteases, Mmp-20 and Klk4 was reduced in the Bmp2 cKO teeth as reflected in a reduced enamel formation. Exogenous Bmp2 up-regulated those gene expressions in mouse enamel organ epithelial cells. This result for the first time indicates Bmp2 signaling is essential for proper enamel development and mineralization in vivo. J. Cell. Physiol. 230: 1871-1882, 2015. (c) 2014 Wiley Periodicals, Inc.
机译：尽管Bmp2对牙齿的形成至关重要,Bmp2在釉质形成的作用依然存在未知的体内。在釉质形成的监管调查Bmp2条件敲除(Bmp2 cKO)老鼠。与不对称严重和深远的表型和畸形门齿的磨损切牙和磨牙。分析表明,搪瓷层发育不全的和搪瓷缺乏典型的棱镜模式。测试的脆性剪切和压缩模。基因,amelogenin enamelin,enamel-processing蛋白酶,Mmp-20 Klk4减少在Bmp2 cKO的牙齿是反映在一个降低牙釉质的形成。差异基因表达的老鼠搪瓷器官上皮细胞。第一次表明Bmp2信号适当的搪瓷发展至关重要矿化体内。1871 - 1882年,2015年。

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