Anthropometric, Metabolic and Molecular Determinants of Human Epidermal Growth Factor Receptor 2 Expression in Luminal B Breast Cancer

Vici Patrizia; Crispo Anna; Giordano AntonioDi Lauro LuigiSperati FrancescaTerrenato IrenePizzuti LauraSergi DomenicoMottolese MarcellaBotti ClaudioGrimaldi MariaCapasso ImmacolataDAiuto GiuseppeDi Bonito MaurizioDi Paola FlavianoMaugeri-Sacca MarcelloMontella MaurizioBarba Maddalena

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Anthropometric, Metabolic and Molecular Determinants of Human Epidermal Growth Factor Receptor 2 Expression in Luminal B Breast Cancer

机译：人体代谢和分子人类表皮生长因子的决定因素B受体2表达在细胞腔的乳腺癌

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Genomic and trascriptomic profiling has recently contributed details to the characterization of luminal B breast cancer. We explored the contribution of anthropometric, metabolic, and molecular determinants to the multifaceted heterogeneity of this breast cancer subtype, with a specific focus on the association between body mass index (BMI), pre-treatment fasting glucose, hormone receptors, and expression of human epidermal growth factor receptor 2 (HER2). Extensively annotated specimens were obtained from 154 women with luminal B breast cancer diagnosed at two Italian comprehensive cancer centres. Participants' characteristics were descriptively analyzed overall and by HER2 status (positive vs. negative). BMI (<25 vs 25), pre-treatment fasting glucose (

机译：基因组和trascriptomic分析最近细节的描述腔的乳腺癌。人体测量的贡献、代谢和分子多方面的因素异质性的乳腺癌亚型一个特定的关注身体之间的关系质量指数(BMI),预处理空腹血糖,激素受体,和人类的表情表皮生长因子受体2 (HER2)。广泛的带注释的标本从154年乳腺癌细胞腔的B两个意大利综合癌症诊断中心。描述性分析整体和HER2状态(积极的和消极的)。预处理空腹血糖(<中值94 mg / dl vs . 94)和激素的比例受体与HER2检测协会在回归模型表达式。模型、体重指数、空腹血糖,较小程度上,雌激素受体(ER)的百分比显著负相关HER2表达(OR: 0.32, 95% CI: 0.16—-0.66;0.43, 0.23 - -0.82;多变量模型证实了防护BMI和ER在HER2表达的作用腔的B HER2阳性患者女性更频繁最高类别的BMI和百分比ER的表达与同行相比(例如:0.22,95% CI: 0.09-0.53;在结论中,BMI和ER的百分比表示与HER2负相关表达在乳腺癌细胞腔的B。确认结果,这可能帮助识别病人子组最好可能受益使用针对胰岛素抵抗的干预措施在乳腺癌的场景描述。细胞。威利期刊公司。

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来源
《Journal of Cellular Physiology》 |2015年第8期|1708-1712|共5页
作者
Vici Patrizia; Crispo Anna; Giordano AntonioDi Lauro LuigiSperati FrancescaTerrenato IrenePizzuti LauraSergi DomenicoMottolese MarcellaBotti ClaudioGrimaldi MariaCapasso ImmacolataDAiuto GiuseppeDi Bonito MaurizioDi Paola FlavianoMaugeri-Sacca MarcelloMontella MaurizioBarba Maddalena;
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G Pascale Fdn Natl Canc Inst, Dept Pathol, Naples, Italy;

G Pascale Fdn Natl Canc Inst, Breast Unit, Naples, Italy;

Regina Elena Inst Canc Res, Dept Pathol, I-00144 Rome, ItalyG Pascale Fdn Natl Canc Inst, Epidemiol Unit, Naples, ItalyRegina Elena Inst Canc Res, Div Med Oncol B, I-00144 Rome, ItalyRegina Elena Inst Canc Res, Dept Surg, I-00144 Rome, ItalyG Pascale Fdn Natl Canc Inst, Dept Diagnost & Clin Pathol, Naples, ItalyRegina Elena Inst Canc Res, Biostat Sci Direct, I-00144 Rome, ItalyRegina Elena Inst Canc Res, Div Med Oncol B, Sci Direct, I-00144 Rome, ItalyTemple Univ, Coll Sci & Technol, Sbarro Inst Canc Res & Mol Med, Philadelphia, PA 19122 USA;

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正文语种英语
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luminal B breast cancer; Erbium; Growth Factor ReceptorsHormone ReceptorBMIReceptor, ErbB-2Breast CancererbB-2 GenesBody Mass Index;

机译：腔的B乳腺癌;铒;生长因子ReceptorsHormone ReceptorBMIReceptor,ErbB-2Breast CancererbB-2 GenesBody质量指数;

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1. EGFR antisense RNA blocks expression of the epidermal growth factor receptor and partially reverse the malignant phenotype of human breast cancer MDA—MB—231 cells [J] . FANWENHONG, YINGLINLU, 等细胞研究：英文版 . 1998,第001期
2. Human epidermal growth factor receptor type 2 protein expression in Chinese metastatic prostate cancer patients correlates with cancer specific survival and increases after exposure to hormonal therapy [J] . Bo Dai, Yun-Yi Kong, Ding-Wei Ye, 亚洲男性学杂志（英文版） . 2008,第005期
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机译：上皮细胞成长因子「Epidermal Growth Factor」
4. 上皮細胞成長因子「Epidermal Growth Factor」 [J] . フレグランスジャ—ナル . 2007,第3期

机译：上皮细胞成长因子「Epidermal Growth Factor」
5. 乳癌幹細胞と分子標的治療Breast cancer stem cell and molecular targeted therapy [J] . 後藤典子细胞 . 2010,第5期

机译：乳癌干细胞と分子标的治疗Breast cancer stem cell and molecular targeted therapy
6. Hepatocyte growth factor reduces susceptibility to an irreversible epidermal growth factor receptor inhibitor in EGFR-T790M mutant lung cancer [O] . Yamada, Tadaaki, Matsumoto, Kunio, Wang, Wei, 2010

机译：Hepatocyte growth factor reduces susceptibility to an irreversible epidermal growth factor receptor inhibitor in EGFR-T790m mutant lung cancer
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机译：Cyclin D1，anchorage-Independent Growth和Breast Cancer。

Anthropometric, Metabolic and Molecular Determinants of Human Epidermal Growth Factor Receptor 2 Expression in Luminal B Breast Cancer

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