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首页> 外文期刊>Journal of Cellular Physiology >Concise Review: The Role of Oxygen in Hematopoietic Stem Cell Physiology
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Concise Review: The Role of Oxygen in Hematopoietic Stem Cell Physiology

机译：简洁回顾:氧气的作用造血干细胞生理

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摘要

Molecular dioxygen, O-2, is an important element in cellular microenvironment in vivo, and often overlooked in standard in vitro and ex vivo cell culture systems. Molecular oxygen is the ultimate electron acceptor in oxidative cellular respiration, and also a signal that regulates cell fate through concentration gradients. Recent advances in physiology of oxygen and adult stem cell research have shown that apart from being important for oxidative phosphorylation, thus energy metabolism, oxygen is also important as a signaling molecule and an integral part of the stem cell niche. This review article covers the influence of physiologically relevant oxygen levels on adult stem cells through highlighting the research on the effect of oxygen concentration on hematopoietic stem cell maintenance, proliferation and differentiation. This is important particularly to understand the embryonic and adult stem cell biology and physiology. The new discoveries in this field will help to further improve current tissue engineering and clinical applications. In addition, understanding the relationship between oxygen and stemness is invaluable for the advanced treatments of neoplastic diseases. Authors believe that in the future, active and programmed dynamic of oxygen levels will be routinely used for the programmed in vitro and ex vivo expansion of different adult stem cell types and tissue regeneration purposes. J. Cell. Physiol. 230: 1999-2005, 2015. (c) 2015 Wiley Periodicals, Inc.
机译：分子分子氧,0 2,是一个重要的元素在细胞体内微环境,经常忽略了在标准体外和体外细胞文化系统。电子受体在细胞氧化呼吸,同时调节的信号通过浓度梯度细胞命运。生理学的进步的氧气和成人干细胞细胞的研究表明,除了重要的氧化磷酸化,从而能量代谢、氧气也是重要的信号分子和不可或缺的一部分干细胞利基。生理上的影响相关的氧通过强调成人干细胞水平研究氧的影响浓度对造血干细胞维护、增殖和分化。这是很重要的,特别了解胚胎和成年干细胞生物学和生理机能。将有助于进一步改善目前的组织工程和临床应用。另外,理解之间的关系氧气和具备干细胞是非常宝贵的先进的肿瘤疾病的治疗。作者认为,在未来,积极动态编程的氧气水平经常用于编程体外和交货体内不同的成年干细胞类型的扩张和组织再生的目的。杂志。230:1999 - 2005年,2015年。期刊、公司。

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