Drosophila as a Model for Context-Dependent Tumorigenesis

HARLA TIPPING; NORBERT PERR1MON

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Drosophila as a Model for Context-Dependent Tumorigenesis

机译：果蝇作为上下文相关的模型肿瘤发生

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Drosophila can exhibit classic hallmarks of cancer, such as evasion of apoptosis, sustained proliferation, metastasis, prolonged survival, genome instability, and metabolic reprogramming, when cancer-related genes are perturbed. In the last two decades, studies in flies have identified several tumor suppressor and oncogenes. However, the greatest strength of the fly lies in its ability to model cancer hallmarks in a variety of tissue types, which enables the study of context-dependent tumorigenesis. We review the organs and tissues that have been used to model tumor formation, and propose new strategies to maximize the potential of Drosophila in cancer research.

机译：果蝇可以表现出的典型特征癌症,如逃避凋亡,持续扩散、转移、长期生存,基因组不稳定,代谢重编程,当癌症相关基因是摄动。近二十年来,果蝇的研究一些肿瘤抑制和识别致癌基因。飞癌症特征在于其能力模型在不同的组织类型,使研究上下文相关的肿瘤发生。审查已使用的器官和组织肿瘤形成模型,并提出新的策略的潜力最大化在癌症研究果蝇。

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《Journal of Cellular Physiology》 |2014年第1期|27-33|共7页
作者
HARLA TIPPING; NORBERT PERR1MON;
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作者单位

Department of Genetics, Harvard Medical School, Boston, Massachusetts;

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正文语种英语
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关键词
Drosophila; Flies; Neoplastic Cell Transformationcancer researchHallmarkingTumor Suppressor GenesHLA TypingGenomic Instability;

机译：果蝇,苍蝇;肿瘤细胞Transformationcancer researchHallmarkingTumor抑制GenesHLA TypingGenomic不稳定;

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1. The miR-183～96～182 cluster promotes tumorigenesis in a mouse model of medulloblastoma [J] . Zengdi Zhang, Sanen Li, Steven Y Cheng 生物医学研究杂志（英文版） . 2013,第006期
2. The miR-183--96-182 cluster promotes tumorigenesis in a mouse model of medulloblastoma [J] . Zengdi Zhang, Sanen Li, Steven Y Cheng 生物医学研究杂志：英文版 . 2013,第006期
3. Suppression of tumorigenesis by human mesenchymal stem cells in a hepatoma model [J] . Ling Qiao, Zhili Xu, Tiejun Zhao, 细胞研究（英文版） . 2008,第004期
4. How Does Multistep Tumorigenesis Really Proceed? [J] . Christine L. Chaffer, Robert A. Weinberg Cancer reviews . 2015,第Feba期

机译：MultiSep TumorigeNesis如何确实继续？
5. Two new species in the Drosophila flavopilosa and Drosophila morelia species groups (Diptera: Drosophilidae) in the eastern Andes of Ecuador [J] . Ramos Guill?-n Emily, Rafael Violeta Revista Peruana de Biologia . 2018,第2期

机译：厄瓜多尔东部安第斯山脉的果蝇（Drosophila flavopilosa）和果蝇（Drosophila morelia）物种组中的两个新物种（双翅目：Drosophilidae）
6. The Drosophila TIPE family member Sigmar interacts with the Ste20-like kinase Misshapen and modulates JNK signaling, cytoskeletal remodeling and autophagy The Drosophila TIPE family member Sigmar interacts with the Ste20-like kinase Misshapen and modulates JNK signaling, cytoskeletal remodeling and autophagy The Drosophila TIPE family member Sigmar interacts with the Ste20-like kinase Misshapen and modulates JNK signaling, cytoskeletal remodeling and autophagy [J] . Chandra Lebovitz, Sharon M. Gorski, Lindsay DeVorkin, Biology Open . 2015,第5期

机译：果蝇TIPE家族成员Sigmar与Ste20样激酶Misshapen相互作用并调节JNK信号传导，细胞骨架重塑和自噬Drosophila TIPE家族成员Sigmar与Ste20样激酶Misshapen相互作用并调节JNK信号传导，细胞骨架重塑和自噬Drosophila TIPE家族成员Sigmar与Ste20样激酶misshapen相互作用并调节JNK信号传导，细胞骨架重塑和自噬
7. Dual-color on-chip light sheet microscopy of drosophila embryos [C] . Petra Paiè, Roberto Memeo, Federico Sala, Conference on Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues . 2020

机译：Drosophila胚胎的双色片上灯纸显微镜显微镜
8. Extending Boundaries of Emission and Dispersion Modelling with Uncertainty Analysis and Data-Driven Models =利用不确定性分析和数据驱动模型拓展尾气排放和扩散模型的应用范围 [D] . Wang, An. 2021

机译：Extending Boundaries of Emission and Dispersion Modelling with Uncertainty Analysis and Data-Driven Models =利用不确定性分析和数据驱动模型拓展尾气排放和扩散模型的应用范围
9. Development of a new quantitative structure–activity relationship model for predicting Ames mutagenicity of food flavor chemicals using StarDrop™ auto-Modeller™ [O] . Toshio Kasamatsu, Airi Kitazawa, Sumie Tajima, 2021

机译：使用Stardrop™Auto-Modeller™预测食品风味化学品的AME致突变性的新定量结构 - 活动关系模型
10. Tenascin-C Downregulates Wnt Inhibitor Dickkopf-1, Promoting Tumorigenesis in a Neuroendocrine Tumor Model [O] . Falk Saupe, Anja Schwenzer, Yundan Jia, 2013

机译：Tenascin-C Downregulates Wnt Inhibitor Dickkopf-1, promoting Tumorigenesis in a Neuroendocrine Tumor model
11. Genes for Male Accessory Gland Proteins in Drosophila Melanogaster. [R] . Wolfner, M. F., Lung, O., Tram, K. U. 2005

机译：果蝇（Drosophila melanogaster）中雄性附属腺蛋白的基因。

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Drosophila as a Model for Context-Dependent Tumorigenesis

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