Core binding factor β (CBFβ) is retained in the midbody during cytokinesis

Lopez-CamachoC.; vanWijnenA.J.; LianJ.B.SteinJ.L.SteinG.S.

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Core binding factor β (CBFβ) is retained in the midbody during cytokinesis

机译：核心绑定因子β(CBFβ)是保留的中间体在胞质分裂

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Core Binding Factor β (CBFβ) is complexed with the RUNX family of transcription factors in the nucleus to support activation or repression of genes related to bone (RUNX2), hematopoiesis (RUNX1) and gastrointestinal (RUNX3) development. Furthermore, RUNX proteins contribute to the onset and progression of different types of cancer. Although CBFβ localizes to cytoskeletal architecture, its biological role in the cytoplasmic compartment remains to be established. Additionally, the function and localization of CBFβ during the cell cycle are important questions relevant to its biological role. Here we show that CBFβ dynamically distributes in different stages of cell division and importantly is present during telophase at the midbody, a temporal structure important for successful cytokinesis. A functional role for CBFβ localization at the midbody is supported by striking defects in cytokinesis that include polyploidy and abscission failure following siRNA-mediated downregulation of endogenous CBFβ or overexpression of the inv(16) fusion protein CBFβ-SMMHC. Our results suggest that CBFβ retention in the midbody during cytokinesis reflects a novel function that contributes to epigenetic control.

机译：核心绑定因子β(CBFβ)包裹着RUNX家族的转录因子核支持激活或镇压与骨相关基因(RUNX2)造血作用(RUNX1)和胃肠道(RUNX3)发展。此外,RUNX蛋白质做出贡献不同类型的发展癌症。架构,其生物作用胞质间还有待建立。本地化的CBFβ细胞周期期间重要的问题相关的生物的角色。分布在不同的细胞分裂阶段在末期,重要的是礼物中间体,重要的时间结构成功的胞质分裂。CBFβ本地化支持中间体胞质分裂,包括缺陷多倍体和离层失败后的差别siRNA-mediated对这些内生CBFβ或超表达的发票(16)融合蛋白CBFβ-SMMHC。胞质分裂期间保留的中间体反映了一种新颖的功能,导致表观遗传控制。

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来源
《Journal of Cellular Physiology》 |2014年第10期|1466-1474|共9页
作者
Lopez-CamachoC.; vanWijnenA.J.; LianJ.B.SteinJ.L.SteinG.S.;
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作者单位

Department of Biochemistry and Vermont Cancer Center, University of Vermont College of Medicine;

Departments of Orthopedic Surgery and Biochemistry and Molecular Biology, Mayo Clinic, Rochester;

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正文语种英语
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关键词
Cytokinesis; Core Binding Factor alpha Subunits; Core Binding FactorsCell DivisionCell CyclePolyploidyTelophase;

机译：胞质分裂;核心因子α有约束力子单元;核心绑定FactorsCell DivisionCellCyclePolyploidyTelophase;

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1. Inhibition of cytokinesis by overexpression of NudCL that is localized to the centrosome and midbody [J] . Yuqi Cai, Yuehong Yang, Minhong Shen, 细胞研究：英文版 . 2009,第011期
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3. A peptide containing the receptor binding site of insulin-like growth factor binding protein-2 enhances bone mass in ovariectomized rats [J] . Gang Xi, Christine Wai, Clifford J.Rosen, 骨研究：英文 . 2018,第003期
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5. Nucleosomal Context of Binding Sites Influences Transcription Factor Binding Affinity and Gene Regulation [J] . Zhiming Dai, Xianhua Dai, Qian Xiang, 基因组蛋白质组与生物信息学报：英文版 . 2009,第004期
6. ORCADIAN CLOCK-ASSOCIATED 1 and LATE ELONGATED HYPOCOTYL regulate expression of the C-REPEAT BINDING FACTOR (CBF) pathway in Arabidopsis [J] . Malia A. Dong, Eva M. Farre, Michael F. Thomashow Proceedings of the National Academy of Sciences of the United States of America . 2011,第17期

机译：ORCADIAN时钟关联1和晚期加长的卵磷脂调节拟南芥中C-REPEAT BINDING FACTOR（CBF）途径的表达
7. Final stages of cytokinesis and midbody ring formation are controlled by BRUCE [J] . Pohl C, Jentsch S Cell . 2008,第5期

机译：Cytokinesis和Midbody ring形成的最终阶段由布鲁斯控制
8. A novel role for the CBF3 kinetochore–scaffold complex in regulating septin dynamics and cytokinesis [J] . Amethyst N. Gillis, Scott Thomas, Scott D. Hansen, Journal of cell biology . 2005,第5期

机译：CBF3 Kinetochore-Scaffold复合物在调节Septin Dynamics和Cytokinesis中的一种新颖作用
9. CIRCADIAN CLOCK-ASSOCIATED 1 and LATE ELONGATED HYPOCOTYL regulate expression of the C-REPEAT BINDING FACTOR (CBF) pathway in Arabidopsis [O] . Malia A. Dong, Eva M. Farré, Michael F. Thomashow 2011

机译：Circadian时钟关联1和晚期加长的hypocotyl调节拟南芥中C-REPEAT BINDING FACTOR（CBF）途径的表达。
10. CIRCADIAN CLOCK-ASSOCIATED 1 and LATE ELONGATED HYPOCOTYL regulate expression of the C-REPEAT BINDING FACTOR (CBF) pathway in Arabidopsis [O] . Dong, Malia A., Farré, Eva M., Thomashow, Michael F. 2011

机译：Circadian时钟关联1和晚期加长的hypocotyl调节拟南芥中C-REPEAT BINDING FACTOR（CBF）途径的表达。

Core binding factor β (CBFβ) is retained in the midbody during cytokinesis

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