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DC-STAMP, the key fusion-mediating molecule in osteoclastogenesis

机译：DC-STAMP,关键fusion-mediating分子osteoclastogenesis

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摘要

As a member of the mononuclear phagocyte system, osteoclasts (OC) absorb the bone matrix and participate in bone modeling by keeping a balance with osteoblasts (OB) and stromal cells. Mature OC derive from the fusion of mononuclear osteoclasts (mOC) and the fusion is considered as the indispensable process for the osteoclastogenesis and absorbing activity of OC. DC-STAMP (dendritic cell-specific transmembrane protein) has been validated playing a key role in the fusion of mOC. DC-STAMP is mainly expressed in OC, macrophages and dendritic cells (DC). While DC-STAMP was discovered in DC, more attentions have been paid to DC-STAMP in OC in this decade. This review will mainly focus on the function of DC-STAMP in OC. Studies on DC-STAMP in DC may also provide new sight for the study of DC-STAMP in OC. Since the function of DC-STAMP is still poorly understood and few studies have been implemented for illustration, many issues are still unknown and need to be revealed. We will also discuss these questions in this review.
机译：作为单核吞噬细胞系统的一员,破骨细胞吸收骨基质和(OC)参与骨建模通过保持平衡成骨细胞(OB)和基质细胞。OC来源于单核的融合破骨细胞(mOC)和融合被认为是必不可少的过程osteoclastogenesis OC和吸收活动。DC-STAMP(树突特异性跨膜蛋白质)验证中扮演重要角色商务部的融合。在OC、巨噬细胞和树突细胞(DC)。虽然DC-STAMP发现于直流,更多已经注意到DC-STAMP OC这十年。函数的DC-STAMP OC。在华盛顿也研究提供新的视野DC-STAMP OC。仍然知之甚少,很少有研究实现说明,许多问题还不清楚,需要披露。在本文也讨论这些问题。

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