Signals controlling un-differentiated states in embryonic stem and cancer cells: Role of the phosphatidylinositol 3′ kinase pathway

VoskasD.; LingL.S.; WoodgettJ.R.

首页> 外文期刊>Journal of Cellular Physiology >Signals controlling un-differentiated states in embryonic stem and cancer cells: Role of the phosphatidylinositol 3′ kinase pathway

【24h】

Signals controlling un-differentiated states in embryonic stem and cancer cells: Role of the phosphatidylinositol 3′ kinase pathway

机译：信号控制un-differentiated州:胚胎干细胞和癌症细胞的作用磷脂酰肌醇3激酶途径

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The capacity of embryonic stem (ES) cells to differentiate into cell lineages comprising the three germ layers makes them powerful tools for studying mammalian early embryonic development in vitro. The human body consists of approximately 210 different somatic cell types, the majority of which have limited proliferative capacity. However, both stem cells and cancer cells bypass this replicative barrier and undergo symmetric division indefinitely when cultured under defined conditions. Several signal transduction pathways play important roles in regulating stem cell development, and aberrant expression of components of these pathways is linked to cancer. Among signaling systems, the critical role of leukemia inhibitory factor (LIF) coupled to the Jak/STAT3 (signal transduction and activation of transcription-3) pathway in maintaining stem cell self-renewal has been extensively reviewed. This pathway additionally plays multiple roles in tumorigenesis. Likewise, the phosphatidylinositide 3-kinase (PI3K)/protein kinase B (PKB/Akt) pathway has been determined to play an important role in both stem cell maintenance and tumor development. This pathway is often induced in cancer with frequent mutational activation of the catalytic subunit of PI3K or loss of a primary PI3K antagonist, phosphatase and tensin homolog deleted on chromosome ten (PTEN). This review focusses on roles of the PI3K signal transduction pathway components, with emphasis on functions in stem cell maintenance and cancer. Since the PI3K pathway impinges on and collaborates with other signaling pathways in regulating stem cell development and/or cancer, aspects of the canonical Wnt, Ras/mitogen-activated protein kinase (MAPK), and TGF-β signaling pathways are also discussed.

机译：胚胎干细胞(ES)细胞的能力分化成细胞组成的血统三个胚芽层使他们强大的工具研究哺乳动物早期胚胎发育体外。210种不同体细胞类型,大多数的增殖能力有限。然而,干细胞和肿瘤细胞旁路这个复制的障碍并接受对称无限期部门培养下定义条件。扮演重要角色在调节干细胞开发和异常表达这些途径与癌症的组成部分。在信号系统中,关键的角色白血病抑制因子(生活)耦合Jak / STAT3(信号转导和激活transcription-3)维持干细胞的途径自我更新已经广泛地查阅。另外途径中扮演多个角色肿瘤发生。phosphatidylinositide 3-kinase (PI3K) /蛋白质激酶B (PKB) / Akt通路已经被决定在干细胞起着重要的作用维护和肿瘤的发展。往往是诱发癌症的频繁突变激活的催化亚基PI3K主要PI3K拮抗剂或损失,磷酸酶和tensin同族体删除10号染色体(PTEN)。PI3K信号转导通路的作用组件、阀杆的强调功能电池维护和癌症。途径影响着与其他合作信号通路在调节干细胞开发和/或癌症方面的规范Wnt, Ras /增殖作用激酶(MAPK)和TGF -β信号通路还讨论了。

著录项

来源
《Journal of Cellular Physiology》 |2014年第10期|1312-1322|共11页
作者
VoskasD.; LingL.S.; WoodgettJ.R.;
展开▼
作者单位

Department of Medical Biophysics, University of Toronto, Toronto, Canada;

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类
关键词
Stem Cells; Pathway; Stem Cell DifferentiationCatalytic DomainGerm LayersPhosphatidylinositol 3-KinasesPIK3CA protein, humanPhosphatidylinositolscancer cellSignal Transduction PathwaysCancercell maintenanceCell LineageCirculating Neoplastic CellsPTEN gene;

机译：干细胞;途径;干细胞DifferentiationCatalytic DomainGermLayersPhosphatidylinositol 3-KinasesPIK3CA蛋白质,humanPhosphatidylinositolscancercellSignal转导PathwaysCancercellmaintenanceCell LineageCirculating肿瘤CellsPTEN基因;

相似文献

外文文献
中文文献

1. Signaling Pathways Associated with Cancer Stem Cells Play a Significant Role in Immunotherapy Resistance [J] . Yajuan Zhu#, Yuwen Zhou, Yao Xie, 肿瘤学研究(英文) . 2019,第002期
2. Role of genetic abnormalities of PTEN and the phosphatidylinositol 3 kinase pathway in breast and ovarian cancer tumorigenesis, prognosis and therapy [J] . 细胞研究（英文版） . 2002,第003期
3. Integrin鈥怓AK鈥怌DC42鈥怭P1A signaling gnaws at YAP/TAZ activity to control incisor stem cells [J] . BioEssays : . 2017,第10期

机译：Integrin鈥怓AK鈥怌DC42鈥怭P1A signaling gnaws at YAP/TAZ activity to control incisor stem cells
4. Integrin鈥怓AK鈥怌DC42鈥怭P1A signaling gnaws at YAP/TAZ activity to control incisor stem cells [J] . BioEssays : . 2017,第10期

机译：Integrin鈥怓AK鈥怌DC42鈥怭P1A signaling gnaws at YAP/TAZ activity to control incisor stem cells
5. Retraction: Tanshinone IIA prevents left ventricular remodelling via the TLR4/MyD88/NF‐κB signalling pathway in rats with myocardial infarction. Dong‐Mei Wu, Yong‐Jian Wang, Xin‐Rui Han, Xin Wen, Lei Li, Lan Xu, Jun Lu and Yuan‐Lin Zheng. J Cell Mol Med. 2018; 22: 3058–3072 (https://doi.org/10.1111/jcmm.13557). [J] . Journal of cellular and molecular medicine. . 2021,第2期

机译：Retraction: Tanshinone IIA prevents left ventricular remodelling via the TLR4/MyD88/NF‐κB signalling pathway in rats with myocardial infarction. Dong‐Mei Wu, Yong‐Jian Wang, Xin‐Rui Han, Xin Wen, Lei Li, Lan Xu, Jun Lu and Yuan‐Lin Zheng. J Cell Mol Med. 2018; 22: 3058–3072 (https://doi.org/10.1111/jcmm.13557).
6. Retraction: Tanshinone IIA prevents left ventricular remodelling via the TLR4/MyD88/NF‐κB signalling pathway in rats with myocardial infarction. Dong‐Mei Wu Yong‐Jian Wang Xin‐Rui Han Xin Wen Lei Li Lan Xu Jun Lu and Yuan‐Lin Zheng. J Cell Mol Med. 2018; 22: 3058–3072 (https://doi.org/10.1111/jcmm.13557). [O] . 2021

机译：Retraction: Tanshinone IIA prevents left ventricular remodelling via the TLR4/MyD88/NF‐κB signalling pathway in rats with myocardial infarction. Dong‐Mei Wu Yong‐Jian Wang Xin‐Rui Han Xin Wen Lei Li Lan Xu Jun Lu and Yuan‐Lin Zheng. J Cell Mol Med. 2018; 22: 3058–3072 (https://doi.org/10.1111/jcmm.13557).
7. Role of 17β-estradiol in controlling the self-renewal of undifferentiated mouse embryonic stem cells via calcium signaling pathway. [O] . 2010

机译：Role of 17β-estradiol in controlling the self-renewal of undifferentiated mouse embryonic stem cells via calcium signaling pathway.

Signals controlling un-differentiated states in embryonic stem and cancer cells: Role of the phosphatidylinositol 3′ kinase pathway

摘要

著录项

相似文献

相关主题

期刊订阅