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首页> 外文期刊>Journal of Cellular Physiology >The abbreviated pluripotent cell cycle
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The abbreviated pluripotent cell cycle

机译：缩写多能细胞周期

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Human embryonic stem cells (hESCs) and induced pluripotent stem cells proliferate rapidly and divide symmetrically producing equivalent progeny cells. In contrast, lineage committed cells acquire an extended symmetrical cell cycle. Self-renewal of tissue-specific stem cells is sustained by asymmetric cell division where one progeny cell remains a progenitor while the partner progeny cell exits the cell cycle and differentiates. There are three principal contexts for considering the operation and regulation of the pluripotent cell cycle: temporal, regulatory, and structural. The primary temporal context that the pluripotent self-renewal cell cycle of hESCs is a short G1 period without reducing periods of time allocated to S phase, G2, and mitosis. The rules that govern proliferation in hESCs remain to be comprehensively established. However, several lines of evidence suggest a key role for the na?ve transcriptome of hESCs, which is competent to stringently regulate the embryonic stem cell (ESC) cell cycle. This supports the requirements of pluripotent cells to self-propagate while suppressing expression of genes that confer lineage commitment and/or tissue specificity. However, for the first time, we consider unique dimensions to the architectural organization and assembly of regulatory machinery for gene expression in nuclear microenviornments that define parameters of pluripotency. From both fundamental biological and clinical perspectives, understanding control of the abbreviated ESC cycle can provide options to coordinate control of proliferation versus differentiation. Wound healing, tissue engineering, and cell-based therapy to mitigate developmental aberrations illustrate applications that benefit from knowledge of the biology of the pluripotent cell cycle.
机译：人类胚胎干细胞(为)和诱导多能干细胞增殖迅速,对称分裂产生子代细胞。获得一个扩展对称的细胞周期。组织干细胞的自我更新持续通过不对称细胞分裂仍然是一个祖而子代细胞合作伙伴子代细胞细胞周期和退出区分。考虑到操作和上下文多能细胞周期的调节:时间、监管和结构性的。多能时间上下文自我更新细胞周期G1为是短没有减少的时间分配G2, S期和有丝分裂。在为保持控制扩散全面建立。证据显示的关键作用na吗?严格控制胚胎干细胞(ESC)细胞周期。的多能细胞self-propagate抑制基因的表达血统的承诺和/或组织特异性。但是,第一次,我们认为独特的架构组织和尺寸装配管理机械的基因在核microenviornments表达式定义参数的多能性。基本生物学和临床的角度,理解缩写ESC的控制权周期可以提供选项来协调控制增殖和分化。治疗、组织工程和细胞治疗以减轻发展畸变说明应用程序受益的多能细胞的生物学知识周期。

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