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首页> 外文期刊>Journal of Cellular Physiology >Folic acid enlarges the armamentarium for the treatment of coronary vasospasm
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Folic acid enlarges the armamentarium for the treatment of coronary vasospasm

机译：叶酸扩大的医疗设备治疗冠状动脉血管痉挛

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Qipshidze et al. (2010) described in the Journal of Cell Physiology that folic acid ameliorates acetylcholine-induced vasoconstriction in hyperhomocysteinemic cystathionine beta synthase heterozygote (CBS-/+) mice, and that this effect can be explained by an increase in endothelial nitric oxide (eNOS) expression and nitric oxide (NO) bioavailability in the coronary artery. The authors have investigated the role of eNOS in acetylcholine-induced vasoconstriction in CBS -/+ mice by measuring total protein (by immunolabelling) and mRNA levels (by RT-PCR). However, they did not perform eNOS uncoupling assessment, which is of essential importance to evaluate the active or inactive state of eNOS. Qipshidze et al. (2010) assessed only the NO-pathway using
机译：Qipshidze et al。(2010)在《华尔街日报》描述的细胞生理学的叶酸改善acetylcholine-induced血管收缩在hyperhomocysteinemic胱硫醚β合酶杂合子小鼠(CBS - / +),这种效果可以解释为增加内皮一氧化氮(以挪士)表达和一氧化氮冠状动脉(NO)生物利用度。作者调查的角色以挪士在CBS - / + acetylcholine-induced血管收缩通过测量总蛋白(老鼠immunolabelling)和mRNA水平(rt - pcr)。然而,他们没有执行以挪士解偶联评估,这就显得极其重要评估以挪士的活动或非活动状态。Qipshidze et al。(2010)的评估NO-pathway使用

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