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首页> 外文期刊>Journal of Cellular Physiology >Dynamic distribution of HDAC1 and HDAC2 during mitosis: Association with F-actin
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Dynamic distribution of HDAC1 and HDAC2 during mitosis: Association with F-actin

机译：HDAC1和HDAC2的动态分布有丝分裂:协会与f -肌动蛋白

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摘要

During mitosis, histone deacetylase 2 (HDAC2) becomes highly phosphorylated through the action of CK2, and HDAC1 and 2 are displaced from mitotic chromosomes. HDAC1 and 2 are components of corepressor complexes, which function with lysine acetyltransferases to catalyze dynamic protein acetylation and regulate gene expression. In this study, we show that HDAC1 and 2 associate with F-actin in mitotic cells. Inhibition of Aurora B or protein kinase CK2 did not prevent the displacement of HDAC1 and 2 from mitotic chromosomes in HeLa cells. Further, proteins of the HDAC1 and 2 corepressor complexes and transcription factors recruiting these corepressors to chromatin were dissociated from mitotic chromosomes independent of Aurora B activity. HDAC1 and 2 returned to the nuclei of daughter cells during lamin A/C reassembly and before Sp1, Sp3, and RNA polymerase II. Our results show that HDAC1 and 2 corepressor complexes are removed from the mitotic chromosomes and are available early in the events leading to the re-establishment of the gene expression program in daughter cells.
机译：在有丝分裂过程中,组蛋白脱乙酰酶2 (HDAC2)通过行动成为高度磷酸化CK2和HDAC1和2背井离乡有丝分裂染色体。辅阻遏物复合物的功能赖氨酸乙酰转移酶的催化活力蛋白质乙酰化作用和调节基因的表达。在这项研究中,我们表明,HDAC1和2副与f -肌动蛋白在细胞有丝分裂细胞。Aurora B或蛋白激酶CK2并没有阻止HDAC1和2的位移有丝分裂在海拉细胞染色体。HDAC1和2辅阻遏物复合物转录因子招募这些辅阻遏物染色质是分离的有丝分裂染色体独立Aurora B活动。在核纤层蛋白A / C重新组装和子细胞在Sp1之前,Sp3, RNA聚合酶II。结果表明,HDAC1和2辅阻遏物复合物从细胞有丝分裂中删除染色体和可用的早期事件导致基因的重建在子细胞表达项目。

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