Disruption of immune regulation by microbial pathogens and resulting chronic inflammation

BarthK.; RemickD.G.; GencoC.A.

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Disruption of immune regulation by microbial pathogens and resulting chronic inflammation

机译：破坏微生物的免疫调节病原体和产生的慢性炎症

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Activation of the immune response is a tightly regulated, coordinated effort that functions to control and eradicate exogenous microorganisms, while also responding to endogenous ligands. Determining the proper balance of inflammation is essential, as chronic inflammation leads to a wide array of host pathologies. Bacterial pathogens can instigate chronic inflammation via an extensive repertoire of evolved evasion strategies that perturb immune regulation. In this review, we discuss two model pathogens, Mycobacterium tuberculosis and Porphyromonas gingivalis, which efficiently escape various aspects of the immune system within professional and non-professional immune cell types to establish chronic inflammation.

机译：激活免疫反应的紧功能监管、协调工作控制和消除外源微生物,同时也对内源性配体。确定适当的平衡的炎症必不可少的,如慢性炎症导致广泛的主机病态。病原体可以通过煽动的慢性炎症一个广泛的进化逃税扰乱免疫调节策略。本文,我们将讨论两个模型的病原体,结核分枝杆菌和Porphyromonasgingivalis,有效地逃避各种在专业方面的免疫系统和非专业免疫细胞类型建立慢性炎症。

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《Journal of Cellular Physiology》 |2013年第7期|1413-1422|共10页
作者
BarthK.; RemickD.G.; GencoC.A.;
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作者单位

Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA;

Department of Medicine Section of Infectious Disease, Boston University School of Medicine, Boston;

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原文格式 PDF
正文语种英语
中图分类细胞生物学;
关键词
Immunoregulation; Porphyromonas gingivalis; ProfessionalImmune SystemChronic inflammation;

机译：免疫调节;Porphyromonasgingivalis;ProfessionalImmune SystemChronic炎症;

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Disruption of immune regulation by microbial pathogens and resulting chronic inflammation

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